Gradual Changes of Gut Microbiota in Weaned Miniature Piglets.
Gradual Changes of Gut Microbiota in Weaned Miniature Piglets.
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DOI：
10.3389/fmicb.2016.01727
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发表时间：
2016
影响因子：
5.2
通讯作者：
Yan X
中科院分区：
文献类型：
--
作者：
Hu J;Nie Y;Chen J;Zhang Y;Wang Z;Fan Q;Yan X
哺乳动物早期肠道菌群的定植对宿主健康至关重要。迷你小猪最近被认为是最理想的婴儿模型。然而，对微型仔猪肠道菌群的发育知之甚少。本研究旨在探讨从江小型断奶仔猪肠道菌群的发育情况。与相对稳定的肠道真菌群落相比，肠道细菌群落的α多样性明显下降，并伴随着分类组成的显著变化。随着断奶仔猪年龄的增长，24种细菌的相对丰度显著降低，7种细菌的相对丰度显著升高，分别为纤维菌属、Collinsella、Roseburia、Prevotella、Dorea、Howardella和Blautia。真菌分类分析表明，随着仔猪年龄的增长，2属（Kazachstania和Aureobasidium）的相对丰度显著降低，而4属（Aspergillus、Cladosporium、Simplicillium和Candida）的相对丰度显著升高。在断奶小型仔猪肠道真菌群落中，telluris是主要的特征菌种。随着仔猪年龄的增长，肠道细菌群落的功能成熟表现为消化系统、糖的生物合成和代谢以及维生素B的生物合成显著增加。这些发现表明，从江微型仔猪肠道微生物的显著变化可能有助于了解断奶婴儿肠道微生物群的潜在发育。
Colonization of gut microbiota in mammals during the early life is vital to host health. The miniature piglet has recently been considered as an optimal infant model. However, less is known about the development of gut microbiota in miniature piglets. Here, this study was conducted to explore how the gut microbiota develops in weaned Congjiang miniature piglets. In contrast to the relatively stabilized gut fungal community, gut bacterial community showed a marked drop in alpha diversity, accompanied by significant alterations in taxonomic compositions. The relative abundances of 24 bacterial genera significantly declined, whereas the relative abundances of 7 bacterial genera (Fibrobacter, Collinsella, Roseburia, Prevotella, Dorea, Howardella, and Blautia) significantly increased with the age of weaned piglets. Fungal taxonomic analysis showed that the relative abundances of two genera (Kazachstania and Aureobasidium) significantly decreased, whereas the relative abundances of four genera (Aspergillus, Cladosporium, Simplicillium, and Candida) significantly increased as the piglets aged. Kazachstania telluris was the signature species predominated in gut fungal communities of weaned miniature piglets. The functional maturation of the gut bacterial community was characterized by the significantly increased digestive system, glycan biosynthesis and metabolism, and vitamin B biosynthesis as the piglets aged. These findings suggest that marked gut microbial changes in Congjiang miniature piglets may contribute to understand the potential gut microbiota development of weaned infants.