Equivalent circuit models for a biomembrane impedance sensor and analysis of electrochemical impedance spectra based on support vector regression

Equivalent circuit models for a biomembrane impedance sensor and analysis of electrochemical impedance spectra based on support vector regression
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基于支持向量回归的生物膜阻抗传感器等效电路模型及电化学阻抗谱分析

DOI:
10.1007/s11517-019-01970-7
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发表时间:
2019-04
影响因子:
3.2
通讯作者:
Yong Yang
Yong Yang
中科院分区:
工程技术3区
文献类型:
--
作者:
Ying Xu;Chao Li;Wanxin Mei;Miao Guo;Yong Yang

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In this study, an electrochemical impedance biosensor was developed as a simple and fast method for real-time monitoring of biofilm binding properties via continuous impedance spectroscopy. To prepare the sensing membrane, cells were immobilized onto gold electrodes with nitrocellulose membranes. Different cell growth features were measured with the impedance instrument and analyzed using an equivalent model for data fitting and support vector regression (SVR) for data processing. The collected impedance spectra revealed that the binding attachment areas of cells differ depending on the cell density. Our results demonstrate the usefulness and feasibility of training our impedance-based sensor with a small amount of data to predict the effective area of different biofilms (GE, NGE, and CNGE), with a prediction error of 9.8%.Graphical abstract
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