Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity.
Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity.
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DOI：
10.1007/s13679-017-0247-x
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发表时间：
2017-03
影响因子：
8.8
通讯作者：
Fildes A
中科院分区：
文献类型：
--
作者：
Llewellyn CH;Fildes A
尽管“致肥”环境无处不在，但人类体重存在相当大的可变性。人类体重有很强的遗传基础，有人假设遗传对环境的易感性解释了人类体重的变化，食欲的差异被认为是中介机制；所谓的“行为易感性理论”（BST），由简·沃德尔教授首次提出。这篇综述总结了食欲作为肥胖遗传风险中介的作用的证据。食欲特征的变化从婴儿期就可以观察到，会导致早期体重增加，并且在婴儿期和儿童期具有高度遗传性。通过全基因组关联研究发现的与肥胖相关的常见遗传变异与食欲性状有关，而食欲介导了遗传风险与肥胖之间观察到的部分关联。肥胖是暴饮暴食的遗传易感性和暴露于“致肥性”食物环境之间的相互作用的结果。
There is considerable variability in human body weight, despite the ubiquity of the ‘obesogenic’ environment. Human body weight has a strong genetic basis and it has been hypothesised that genetic susceptibility to the environment explains variation in human body weight, with differences in appetite being implicated as the mediating mechanism; so-called ‘behavioural susceptibility theory’ (BST), first described by Professor Jane Wardle. This review summarises the evidence for the role of appetite as a mediator of genetic risk of obesity. Variation in appetitive traits is observable from infancy, drives early weight gain and is highly heritable in infancy and childhood. Obesity-related common genetic variants identified through genome-wide association studies show associations with appetitive traits, and appetite mediates part of the observed association between genetic risk and adiposity. Obesity results from an interaction between genetic susceptibility to overeating and exposure to an ‘obesogenic’ food environment.