Drosophila gustatory projections are segregated by taste modality and connectivity.
Drosophila gustatory projections are segregated by taste modality and connectivity.
复制标题
果蝇的味觉投射按味觉模式和连接性进行区分。
DOI：
10.7554/elife.78110
复制
发表时间：
2022-05-25
期刊：
影响因子：
7.7
通讯作者：
Scott, Kristin
中科院分区：
文献类型：
--
作者：
Engert, Stefanie;Sterne, Gabriella R.;Bock, Davi D.;Scott, Kristin
味觉感觉神经元检测潜在食物中的热量和有害化合物，并将这些信息传递给大脑以告知喂养决策。为了检查味觉神经元传输和接收的信号，我们利用全脑电子显微镜体积重建了成年果蝇大脑中的味觉轴突及其突触位点。我们重建了右半球长鼻唇瓣的 87 个味觉投影和左半球的 57 个味觉投影，代表了大部分唇瓣味觉轴突。味觉神经元包含几乎相同数量的散布的突触前和突触后位点，味觉轴突之间具有广泛的突触连接。基于形态学和连接性的聚类揭示了六个不同的组，可能代表识别不同味觉模式的神经元。绝大多数突触连接发生在同一组神经元之间。这项研究解决了标签味觉投射的解剖结构，揭示了味觉投射是根据味觉形态进行分离的，并揭示了可能改变味觉信号传递的突触连接。
Gustatory sensory neurons detect caloric and harmful compounds in potential food and convey this information to the brain to inform feeding decisions. To examine the signals that gustatory neurons transmit and receive, we reconstructed gustatory axons and their synaptic sites in the adult Drosophila melanogaster brain, utilizing a whole-brain electron microscopy volume. We reconstructed 87 gustatory projections from the proboscis labellum in the right hemisphere and 57 from the left, representing the majority of labellar gustatory axons. Gustatory neurons contain a nearly equal number of interspersed pre- and postsynaptic sites, with extensive synaptic connectivity among gustatory axons. Morphology- and connectivity-based clustering revealed six distinct groups, likely representing neurons recognizing different taste modalities. The vast majority of synaptic connections are between neurons of the same group. This study resolves the anatomy of labellar gustatory projections, reveals that gustatory projections are segregated based on taste modality, and uncovers synaptic connections that may alter the transmission of gustatory signals.