Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse.
Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse.
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DOI：
10.1186/1475-2867-13-60
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发表时间：
2013-06-15
影响因子：
5.8
通讯作者：
Sun Q
中科院分区：
文献类型：
--
作者：
Zhong Y;Lin Y;Shen S;Zhou Y;Mao F;Guan J;Sun Q
醛脱氢酶1 （ALDH1）表型对乳腺癌转移行为和早期肿瘤复发的具体机制目前尚不清楚。随机选择147例浸润性导管癌，检测ALDH1A1、NOTCH1、雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体（HER2）的表达，进一步评价ALDH1A1表型与临床病理特征的相关性。147例肿瘤中有93例（63.3%）检测到aldh1a1阳性细胞。80.0%（32 / 40）的ALDH1A1阳性肿瘤显示早期复发，而20.0%（8 / 40）的ALDH1A1阴性肿瘤显示早期复发（P = 0.027）。ALDH1A1水平与强恶性增殖标志物Ki67染色显著相关（P = 0.001），且ALDH1A1在不同ER、PR、HER2亚型的表达及肿瘤组织的三阴性特征无显著差异。多因素回归分析表明，ALDH1A1表达升高是无复发生存和无远处转移生存的独立预测因子。值得注意的是，与ALDH1A1弱表达的肿瘤组织相比，ALDH1A1强表达的乳腺癌组织的NOTCH1染色较弱（P = 0.002），且ALDH1A1与NOTCH1 mRNA阳性的相关性显著（Pearson相关系数为- 0.337,P = 0.014; Spearman’s rho为- 0.376,P = 0.006）。NOTCH1 mRNA水平升高（使用基于ALDH1A1 2-△△CT值中位数的截断值）与ALDH1A1 mRNA水平降低相关（P = 0.001）。ALDH1A1表型是侵袭性导管癌早期肿瘤复发特征（特别是早期局部复发和远处转移的发生率）的独立预测因子。NOTCH1信号通路可能参与了ALDH1A1表型与浸润性导管癌早期恶性复发的负相关。
The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear. 147 randomly selected invasive ductal carcinoma samples were assayed for expression of ALDH1A1, NOTCH1, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER2), and association of the ALDH1A1 phenotype with clinic pathological features was further evaluated. ALDH1A1-positive cells were detected in 63.3% (93 of 147) of tumors. 80.0% (32 of 40) of tumors with strong ALDH1A1 staining displayed early recurrence, compared with 20.0% (8 of 40) of tumors negative for ALDH1A1 expression (P = 0.027). ALDH1A1 status was significantly correlated with strong malignant proliferative marker Ki67 staining (P = 0.001), and no significantly different expression of ALDH1A1 across the subtypes of ER, PR, and HER2 expression and triple negative features of tumor tissue. Multivariate regression analysis demonstrated that elevated ALDH1A1 expression is an independent predictor of recurrence-free survival and distant metastasis-free survival. Notably, breast cancer tissue strong for ALDH1A1 expression displayed weak NOTCH1 staining compared to ALDH1A1 weak tumor tissue (P = 0.002), and the relationship between ALDH1A1 and NOTCH1 mRNA positivity was significant (Pearson correlation - 0.337, P = 0.014; Spearman’s rho - 0.376, P = 0.006). Elevated NOTCH1 mRNA level (using a cut-off value based on the median ALDH1A1 2-△△CT value) was associated with reduction of ALDH1A1 mRNA level (P = 0.001). The ALDH1A1 phenotype is an independent predictor of early tumor relapse characteristic (specifically, incidence of early local recurrence and distant metastasis) of invasive ductal carcinoma. The NOTCH1 signaling pathway is possibly involved in the negative association of the ALDH1A1 phenotype with early malignant relapse in invasive ductal carcinoma.
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DOI：
10.1186/bcr920
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dontu G;Jackson KW;McNicholas E;Kawamura MJ;Abdallah WM;Wicha MS
通讯作者：
Wicha MS
DOI：
10.1073/pnas.0603806103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Chute, John P.;Muramoto, Garrett G.;McDonnell, Donald P.
通讯作者：
McDonnell, Donald P.
影响因子：
11.2
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Rizzo P;Miao H;D'Souza G;Osipo C;Song LL;Yun J;Zhao H;Mascarenhas J;Wyatt D;Antico G;Hao L;Yao K;Rajan P;Hicks C;Siziopikou K;Selvaggi S;Bashir A;Bhandari D;Marchese A;Lendahl U;Qin JZ;Tonetti DA;Albain K;Nickoloff BJ;Miele L
通讯作者：
Miele L
DOI：
10.1016/j.bbrc.2009.05.048
发表时间：
2009-07-31
影响因子：
3.1
作者：
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通讯作者：
Lo, Wen-Liang
影响因子：
8
作者：
Gallahan, D;Callahan, R
通讯作者：
Callahan, R