Micromanaging abdominal aortic aneurysms.
Micromanaging abdominal aortic aneurysms.
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DOI：
10.3390/ijms140714374
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发表时间：
2013-07-11
影响因子：
5.6
通讯作者：
Tsao PS
中科院分区：
文献类型：
--
作者：
Maegdefessel L;Spin JM;Adam M;Raaz U;Toh R;Nakagami F;Tsao PS
在老龄化的工业化世界，腹主动脉瘤(AAA)疾病对人类发病率和死亡率的贡献有所增加。作为回应，已经启动了特别的努力来确定疾病主动脉的分子和病理生理学特征。这项工作旨在开发新的诊断和治疗策略，以限制AAA的扩张，并最终限制AAA的破裂。来自多个研究小组的贡献揭示了一个复杂的转录和转录后调节环境，这被认为是维持主动脉血管内稳所必需的。最近，新的非编码小RNA，称为microRNAs，已被确定为重要的转录和转录后基因表达抑制因子。MicroRNAs被认为通过促进mRNA降解或抑制翻译来“微调”其目标信使RNA(MRNAs)的翻译输出。随着发现microRNAs在各种疾病的背景下扮演着强大的调节者的角色，将microRNAs作为潜在的治疗实体进行彻底的探索是合乎逻辑的。这篇综述总结了关于在AAA启动和繁殖过程中微RNA表达调控的有趣的作用和好处的有趣的发现。这些研究利用了与疾病相关的小鼠模型，以及接受主动脉瘤手术修复的患者的人体组织。此外，我们还就临床和翻译的可行性对未来的治疗策略进行了批判性的研究。
The contribution of abdominal aortic aneurysm (AAA) disease to human morbidity and mortality has increased in the aging, industrialized world. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of the diseased aorta. This work aims to develop novel diagnostic and therapeutic strategies to limit AAA expansion and, ultimately, rupture. Contributions from multiple research groups have uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining aortic vascular homeostasis. Recently, novel small noncoding RNAs, called microRNAs, have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. MicroRNAs are thought to “fine tune” the translational output of their target messenger RNAs (mRNAs) by promoting mRNA degradation or inhibiting translation. With the discovery that microRNAs act as powerful regulators in the context of a wide variety of diseases, it is only logical that microRNAs be thoroughly explored as potential therapeutic entities. This current review summarizes interesting findings regarding the intriguing roles and benefits of microRNA expression modulation during AAA initiation and propagation. These studies utilize disease-relevant murine models, as well as human tissue from patients undergoing surgical aortic aneurysm repair. Furthermore, we critically examine future therapeutic strategies with regard to their clinical and translational feasibility.
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DOI：
10.1042/cs20090372
发表时间：
2010-03-09
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Daugherty A;Rateri DL;Charo IF;Owens AP;Howatt DA;Cassis LA
通讯作者：
Cassis LA
影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
影响因子：
10.8
作者：
Cheng, Wen-Pin;Wang, Bao-Wei;Shyu, Kou-Gi
通讯作者：
Shyu, Kou-Gi
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
4.8
作者：
Chang, Kuo-Wei;Kao, Shou-Yen;Lin, Shu-Chun
通讯作者：
Lin, Shu-Chun