Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states.
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states.
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DOI：
10.1084/jem.154.2.552
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发表时间：
1981-08-01
期刊：
影响因子：
--
通讯作者：
Cazenave PA
中科院分区：
文献类型：
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作者：
Bernabé RR;Coutinho A;Martinez-A C;Cazenave PA
在有限稀释分析中，在正常或用抗原 (Ab1)、独特型 (Ab2) 或单克隆抗独特型抗体 (Ab3) 免疫的 BALB/c 小鼠中研究了产生抗三硝基苯基抗体或 MOPC460 独特型的脂多糖反应性 B 细胞前体的绝对频率。抗独特型免疫导致相关独特型的 B 细胞前体受到抑制，抗（抗独特型）免疫导致前体 B 细胞频率增加 10 倍，而产生抗体的前体的增加相对较低。这一发现只能通过不同免疫状态下 B 细胞区室的组成的变化来解释。
In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti- trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti- idiotype immunity results in the suppression of the B cell precursors for the relevant idiotype, and anti-(anti-idiotype) immunity leads to a 10-fold increase in precursor B cell frequencies, with a comparatively lower increase in antibody-producing precursors. The findings can only be explained by variations in the composition of the B cell compartment in the various immune states.