Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis.
Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis.
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DOI：
10.1055/s-0033-1351324
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Taché Y
中科院分区：
文献类型：
--
作者：
Stengel A;Taché Y
饥饿和饱腹感以一种复杂的方式受到一些食物摄入刺激（促食）和大量抑制（厌食）因子的调节，这些因子在外周（主要在胃肠道）或直接在大脑中产生。在大脑中，下丘脑作为食物摄入调节因子的生产基地起着关键作用。重要的是，该部位整合了外周和中枢信号因子，以协调食物摄入和长期体重。我们对这些调控途径的认识不是静态的，而是随着新因素以及已知递质的上行和下行信号通路的发现而迅速变化的。下丘脑核结合蛋白2 （NUCB2）是nesfatin-1的前体，于2006年首次被发现，nesfatin-1是一种新的食物摄入和体重的厌氧调节剂。最初的报告激发了几个研究小组对nesfatin-1的生物作用进行研究，随后的研究描绘了其减少食物摄入作用的潜在大脑机制。令人感兴趣的是，NUCB2也在下丘脑室旁核发挥其厌氧作用，并在该部位受到代谢状态变化的调节，其昼夜节律与大鼠的摄食成反比。本文综述了目前关于nesfatin-1对食物摄入和体重影响的研究现状，并强调了nesfatin-1作用中细胞信号传导机制的重要缺失环节。
Hunger and satiety are regulated in a complex fashion by a few food intake stimulatory (orexigenic) and a multitude of inhibitory (anorexigenic) factors produced in the periphery (mainly in the gastrointestinal tract) or directly in the brain. Within the brain, the hypothalamus plays a pivotal role as a production site of food intake regulatory factors. Importantly, this site integrates peripheral and central signaling factors to orchestrate food intake and in the long term body weight. Our knowledge on these regulatory pathways is not static but rather rapidly changing as new factors as well as upand downstream signaling pathways of already known transmitters are uncovered. Hypothalamic nucleobindin2 (NUCB2), the precursor of nesfatin-1, was first described in 2006 and nesfatin-1 found to be a novel anorexigenic modulator of food intake and body weight. The initial report stimulated several groups to investigate the biological actions of nesfatin-1 and subsequent studies delineated the underlying brain mechanisms involved in its food reducing effect. Of interest was the demonstration that NUCB2 also exerts its anorexigenic action in the paraventricular nucleus of the hypothalamus and is regulated at this site by changes in metabolic status with a diurnal rhythm inversely related to that of feeding in rats. The present review describes the current state-of-knowledge on central nesfatin-1’s effects on food intake and body weight and highlights important missing links regarding cellular signaling mechanisms involved in nesfatin-1’s action.
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影响因子：
3
作者：
Inhoff, Tobias;Moennikes, Hubert;Noetzel, Steffen;Stengel, Andreas;Goebel, Miriam;Dinh, Q. Thai;Riedl, Andrea;Bannert, Norbert;Wisser, Anna-Sophia;Wiedenmann, Bertram;Klapp, Burghard F.;Tache, Yvette;Kobelt, Peter
通讯作者：
Kobelt, Peter
影响因子：
29
作者：
Maejima, Yuko;Sedbazar, Udval;Yada, Toshihiko
通讯作者：
Yada, Toshihiko
影响因子：
3.3
作者：
Foo, K. S.;Brismar, H.;Broberger, C.
通讯作者：
Broberger, C.
影响因子：
2.9
作者：
KIRCHGESSNER, AL;SCLAFANI, A
通讯作者：
SCLAFANI, A
影响因子：
3.1
作者：
Mohan, Haneesha;Unniappan, Suraj
通讯作者：
Unniappan, Suraj