The effects of dehydration on brain volume - Preliminary results
The effects of dehydration on brain volume - Preliminary results
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DOI：
10.1055/s-2004-821318
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发表时间：
2005-07-01
影响因子：
2.5
通讯作者：
Griffiths, PD
中科院分区：
文献类型：
--
作者：
Dickson, JM;Weavers, HM;Griffiths, PD
在成年人中，头骨是一个固定大小的刚性骨穹顶，因此，脑内体积是一个常数，等于脑体积、脑脊液体积和脑内血量的总和。这三个脑室的体积可能会发生显着变化，这可能会影响颅脑损伤后对脑损伤的易感性。这是首次研究脱水与大脑和脑室体积变化之间的关系。6名健康对照受试者在环境舱中进行了一段时间的运动前后的脑部磁共振成像。受试者由于出汗导致水分流失，体重减少了2.1%到2.6%。我们发现脱水程度与脑室容量变化之间存在相关性(r=0.932，p=0.007)。脱水引起的脑室容量的变化比正常水分的健康对照受试者的日常波动要大得多。
in adults the cranium is a rigid bony vault of fixed size and therefore the intra-cranial volume is a constant which equals the sum of the volume of the brain, the intra-cranial volume of CSF and the intra-cranial volume of blood. There can be marked changes in the volumes of these three intra-cranial compartments which may influence susceptibility to brain damage after head injury. This is the first study to investigate the relationship between dehydration and changes in the volume of the brain and the cerebral ventricles. Six healthy control subjects underwent magnetic resonance imaging of the brain before and after a period of exercise in an environmental chamber. The subjects lost between 2.1 % and 2.6% of their body mass due to water loss through sweating. We found a correlation between the degree of dehydration and the change in ventricular volume (r=0.932, p = 0.007). The changes in ventricular volume caused by dehydration were much larger than those seen in day-to-day fluctuations in a normally hydrated healthy control subject.