Physical frailty and cognitive impairment in older nursing home residents: a latent class analysis.
Physical frailty and cognitive impairment in older nursing home residents: a latent class analysis.
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DOI：
10.1186/s12877-021-02433-1
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发表时间：
2021-09-07
期刊：
影响因子：
4.1
通讯作者：
Ulbricht CM
中科院分区：
文献类型：
--
作者：
Yuan Y;Lapane KL;Tjia J;Baek J;Liu SH;Ulbricht CM
在美国老年疗养院（NH）居民中，人们对身体虚弱的异质性临床特征及其与认知障碍的关系知之甚少。入院时最小数据集3.0用于识别新入住养老院的预期寿命≥6个月且住院时间≥100天的老年人（n = 871,801）。采用潜在类别分析来确定体质虚弱亚组，以fail - nh项目为指标。确定的身体虚弱亚组与认知障碍之间的关联（通过精神状态/认知表现量表的简短访谈测量：无/轻度；中度；严重），调整人口统计学和临床特征，通过多项逻辑回归估计，并以调整的优势比（aOR）和95%置信区间（ci）表示。在入院的老年养老院居民中，确定了三个身体虚弱亚组：“轻度身体虚弱”（患病率：7.6%），“中度身体虚弱”（患病率：44.5%）和“严重身体虚弱”（患病率：47.9%）。那些“中度身体虚弱”或“严重身体虚弱”的人在不同地点之间移动时需要帮助的可能性很高，而且无法在房间里行走。在“严重身体虚弱”的居民也有更大的可能性肠失禁。与无/轻度认知障碍的老年人相比，中度或重度认知障碍的老年人属于“中度身体虚弱”的几率略高[aOR (95%CI)]中度认知障碍：1.01 (0.99-1.03)；aOR (95%CI)：严重认知障碍：1.03(1.01-1.05)，而“严重身体虚弱”亚组的比例更高[aOR (95%CI)：中度认知障碍：2.41 (2.35-2.47)；aOR (95%CI): 5.74（5.58 ~ 5.90）。研究结果表明，老年疗养院居民身体虚弱的表现存在异质性，并为身体虚弱与认知障碍之间的相互关系提供了新的证据。在线版本包含补充资料，下载地址：10.1186/s12877-021-02433-1。
Little is known about the heterogeneous clinical profile of physical frailty and its association with cognitive impairment in older U.S. nursing home (NH) residents. Minimum Data Set 3.0 at admission was used to identify older adults newly-admitted to nursing homes with life expectancy ≥6 months and length of stay ≥100 days (n = 871,801). Latent class analysis was used to identify physical frailty subgroups, using FRAIL-NH items as indicators. The association between the identified physical frailty subgroups and cognitive impairment (measured by Brief Interview for Mental Status/Cognitive Performance Scale: none/mild; moderate; severe), adjusting for demographic and clinical characteristics, was estimated by multinomial logistic regression and presented in adjusted odds ratios (aOR) and 95% confidence intervals (CIs). In older nursing home residents at admission, three physical frailty subgroups were identified: “mild physical frailty” (prevalence: 7.6%), “moderate physical frailty” (44.5%) and “severe physical frailty” (47.9%). Those in “moderate physical frailty” or “severe physical frailty” had high probabilities of needing assistance in transferring between locations and inability to walk in a room. Residents in “severe physical frailty” also had greater probability of bowel incontinence. Compared to those with none/mild cognitive impairment, older residents with moderate or severe impairment had slightly higher odds of belonging to “moderate physical frailty” [aOR (95%CI)moderate cognitive impairment: 1.01 (0.99–1.03); aOR (95%CI)severe cognitive impairment: 1.03 (1.01–1.05)] and much higher odds to the “severe physical frailty” subgroup [aOR (95%CI)moderate cognitive impairment: 2.41 (2.35–2.47); aOR (95%CI)severe cognitive impairment: 5.74 (5.58–5.90)]. Findings indicate the heterogeneous presentations of physical frailty in older nursing home residents and additional evidence on the interrelationship between physical frailty and cognitive impairment. The online version contains supplementary material available at 10.1186/s12877-021-02433-1.
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影响因子：
2.8
作者：
Kanwar A;Singh M;Lennon R;Ghanta K;McNallan SM;Roger VL
通讯作者：
Roger VL
DOI：
10.1016/j.jamda.2017.06.014
发表时间：
2018-01-01
影响因子：
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作者：
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DOI：
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发表时间：
2009-03-01
影响因子：
6.3
作者：
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DOI：
10.1093/gerona/50a.2.m128
发表时间：
1995-03-01
影响因子：
5.1
作者：
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通讯作者：
PHILLIPS, CD