Dementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
Dementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
复制标题
DOI：
10.1016/j.parkreldis.2004.10.014
复制
发表时间：
2005-06-01
影响因子：
4.1
通讯作者：
Dickson, DW
中科院分区：
文献类型：
--
作者：
Tsuboi, Y;Dickson, DW
路易体痴呆（DLB）和帕金森病痴呆（PDD）的关系是有争议的。在DLB中，痴呆先于帕金森症在PDD中，帕金森症先于痴呆。除了呈现特征之外，诊断措施无法区分DLB和PDD。DLB和PDD之间几乎没有或没有病理学差异。在大多数情况下，皮质路易体（LB）是广泛存在的，并有共存的阿尔茨海默型病理，不足以诊断阿尔茨海默病。鉴于帕金森综合征在PDD中占优势，PDD中黑质中的神经元丢失比DLB更严重。需要进一步的临床病理研究来确定DLB和PDD之间的其他病理差异，并探讨神经炎，基底前脑和纹状体病理在这些临床综合征中的作用。(C)2005爱思唯尔有限公司保留所有权利。
The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism in PDD, Parkinsonism antedates dementia. Other than presenting features, diagnostic measures fail to distinguish DLB from PDD. There are few or no pathologic differences between DLB and PDD. In most cases cortical Lewy bodies (LBs) are widespread and there is coexistent Alzheimer type pathology, insufficient to diagnose Alzheimer's disease. Given the predominance of Parkinsonism in PDD, neuronal loss in the substantia nigra is more severe in PDD than DLB. Further clinicopathologic studies are needed to define other pathologic differences between DLB and PDD and to explore the role of neuritic, basal forebrain and striatal pathology in these clinical syndromes. (C) 2005 Elsevier Ltd. All rights reserved.