Telomere shortening in sleep apnea syndrome
Telomere shortening in sleep apnea syndrome
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DOI：
10.1016/j.rmed.2010.03.025
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Agusti, Alvar
中科院分区：
文献类型：
--
作者：
Barcelo, Antonia;Pierola, Javier;Agusti, Alvar
背景：循环白细胞中的端粒长度（TL）与个体的实际年龄有关，但据信它也反映了一生中氧化应激和炎症的累积负担。据报道，在几种以氧化应激和炎症为特征的慢性疾病中，例如糖尿病和动脉粥样硬化，TL 会缩短。由于这些情况也发生在阻塞性睡眠呼吸暂停综合征 (OSAS) 患者中，因此我们假设 OSAS 患者的 TL 会降低。方法：我们比较了 256 名 OSAS 患者和 148 名未患有 OSAS 的对照患者的 TL。我们还调查了 TL 是否与这些患者中 OSAS 的严重程度、代谢紊乱和/或心血管危险因素的存在有关。结果：OSAS 患者的 TL 显着短于对照组 (p < 0.001)。在调整年龄、体重指数、胆固醇、甘油三酯、葡萄糖和尿酸水平、吸烟状况以及动脉高血压的存在后，这种差异仍然存在（p = 0.018）。通过呼吸暂停低通气指数、夜间氧饱和度和白天嗜睡来评估，TL 与 OSAS 的严重程度无关。结论：OSAS 患者循环白细胞中的 TL 比非 OSAS 受试者短。这一观察结果的机制尚未解决，因为它似乎与实际年龄、OSAS 的严重程度和/或心血管或代谢改变的存在无关，但 TL 作为这些患者心血管风险增加的生物标志物的潜在用途证明了进一步研究的合理性。 (C) 2010 Elsevier Ltd. 保留所有权利。
Background: Telomere length (TL) in circulating leukocytes relates to the chronological age of the individual but it is believed to reflect also the cumulative burden of oxidative stress and inflammation over the life-time. Shortening of TL has been reported in several chronic conditions characterized by oxidative stress and inflammation, such as diabetes and atherosclerosis. Because these conditions also occur in patients with Obstructive Sleep Apnea Syndrome (OSAS), we hypothesized that TL would be reduced in patients with OSAS.Methods: We compared TL in 256 patients with OSAS and 148 controls without OSAS. We also investigated if TL was related to the severity of OSAS, the presence of metabolic disorders and/or cardiovascular risk factors in these patients.Results: TL was significantly shorter in patients with OSAS than in controls (p < 0.001). This difference persisted after adjustment for age, body mass index, cholesterol, triglycerides, glucose, and uric acid levels, smoking status and the presence of arterial hypertension (p = 0.018). TL was not related to the severity of OSAS as assessed by the apnea-hypopnea index, nocturnal oxygen saturation and daytime sleepiness.Conclusions: TL in circulating leukocytes is shorter in patients with OSAS than subjects without OSAS. The mechanism of this observation is unresolved since it appears independent of chronological age, the severity of OSAS and/or the presence of cardiovascular or metabolic alterations but the potential utility of TL as a biomarker of increased cardiovascular risk in these patients justifies further studies. (C) 2010 Elsevier Ltd. All rights reserved.