LACTIC DEHYDROGENASES - FUNCTIONS OF 2 TYPES - RATES OF SYNTHESIS OF 2 MAJOR FORMS CAN BE CORRELATED WITH METABOLIC DIFFERENTIATION
LACTIC DEHYDROGENASES - FUNCTIONS OF 2 TYPES - RATES OF SYNTHESIS OF 2 MAJOR FORMS CAN BE CORRELATED WITH METABOLIC DIFFERENTIATION
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DOI：
10.1126/science.143.3609.929
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
GOODFRIEND, TL
中科院分区：
文献类型：
--
作者：
DAWSON, DM;KAPLAN, NO;GOODFRIEND, TL
许多蛋白质的分子异质性，特别是单个酶的异质性，最近已经被清楚地认识到。这些蛋白质的各种形式通常可以通过物理方法分离，但单独的分子物种的生理意义往往是模糊的。然而，对于乳酸脱氢酶(LDH)，不同的分子形式似乎具有不同的功能，并且它们显然与不同的代谢模式有关，并且是特定组织的特征。乳酸脱氢酶的分子形式首先是通过电泳法分离出来的；通过这种方法可以区分多达五种不同的形式。最近的研究表明，事实上只有两种主要或母体形式的乳酸脱氢酶存在。目前的观点是，现在有许多来源的证据支持，
The molecularheterogeneity of many proteins, particularly of individual enzymes, has recently come to be clearly recognized. The various forms of these proteins are usually separable by physi-cal means, but the physiological sig-nificance of the separate molecular species has frequently been obscure. Regarding theenzyme lactic dehydro-genase (LDH), however, the different molecular forms appear to have differ-ent functions and it has become clear that they are associated with different modes of metabolism and are quite characteristic of specific tissues. The molecular forms of LDH were first separated by electrophoresis; by this means up to five separate forms can be distinguished. Recent studies have demonstrated that in fact only two principal or parent forms of LDH exist. The present view, now supported by evidence from many sources, is that