Immediate effects of UV radiation on the skin:: modification by an antioxidant complex containing carotenoids
Immediate effects of UV radiation on the skin:: modification by an antioxidant complex containing carotenoids
复制标题
DOI：
10.1034/j.1600-0781.2003.00044.x
复制
发表时间：
2003-08-01
影响因子：
2.6
通讯作者：
Béjot, M
中科院分区：
文献类型：
--
作者：
Césarini, JP;Michel, L;Béjot, M
背景/目的：阳光的紫外线(UV)部分与皮肤癌的诱发和发展有关，通过减少暴露时间、减少衣物和涂防晒霜可以提供有限的光保护。一种有效、安全、系统的光防护概念将绕过许多缺点。紫外线诱导的氧化应激是DNA损伤的原因之一，少数文献表明，口服抗氧化剂复合体对人类的益处很小，如果有的话，而大量文献在体外或动物模型中显示了有益效果。方法：我们在25名健康人中调查了抗氧化剂复合体(AOC)-维生素(番茄红素、β-胡萝卜素、α-生育酚)、硒-减少紫外线损伤的能力。在7周内每天口服AOC。结果：口服AOC后，光化性红斑阈值升高(+20%，P=0.01)，紫外光诱导红斑明显减轻，紫外光诱导的P53表达降低(P<0.01)。
Background/Aims: The ultraviolet (UV) portion of sunlight is involved in the induction and development of skin cancers against which a limited photoprotection may be provided by reduced time of exposure, clothing, and sunscreen applications. The concept of an effective, safe, systemic photoprotection will circumvent many of the shortcomings. The UV-induced oxidative stress is a cause of DNA damage and a few publications have shown, in humans, minimal benefits, if any, of the oral intake of antioxidant complex, contrasting with the large literature showing beneficial effects in vitro or in animal models.Methods: We investigated, in 25 healthy individuals, the capacity of an antioxidant complex (AOC) - vitamins (lycopene, beta-carotene, alpha-tocopherol), selenium - to reduce UV-induced damages. The AOC was administered orally, daily during 7 weeks. Before and after irradiations, before and after the intake of the product, six parameters were studied: skin color by chromametry, minimal erythemal dose and, on skin biopsies, sunburn cells (SBCs), p53 detected by immunohistochemistry, pigmentation index, and levels of lipoperoxides (thiobarbituric acid reaction).Results: After the oral intake of AOC, we observed an elevation of the actinic erythema threshold (+20%, P =0.01) and a general reduction of the UV-induced erythemas, a reduction of the UV-induced p53 expression (P