Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon
Imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy using laser speckle phenomenon
复制标题
DOI：
10.1007/s10384-007-0521-7
复制
发表时间：
2008-05-01
影响因子：
2.4
通讯作者：
Kishi, Shoji
中科院分区：
文献类型：
--
作者：
Watanabe, Goro;Fujii, Hitoshi;Kishi, Shoji
目的：比较激光散斑血流成像(LSFG)和吲哚青绿血管成像(IA)对息肉状脉络膜血管病(PCV)患者脉络膜血流动力学的影响。方法：对25例PCV患者分别行激光散斑血流图(LSFG)和广野LSFG检查，测量血流速度指标(均方模糊率，MBR)。我们构建了测量过程中四个或五个脉动的连续MBR图像(600x280像素)的MBR图(S 4.5)。通过对MBR图的累加和求平均，得到静止图像的灰度合成图。将灰阶复合图的血管图像与IA结果进行比较，并对MBR图中PCV的25只眼的脉络膜血流动力学进行评价。结果：灰度图上的脉络膜血管与IA结果的分辨率相近。灰度图在25只眼中发现了20只眼(80%)的分支网络血管和11只眼(44%)的息肉状病变。MBR图显示分支网状血管和息肉样病变的搏动与心率同步。脉络膜一次搏动中PCV病变波动率为8.3%~26.7%(平均13.6%)，完整脉络膜为7.3%~24.6%(平均15.9%)。MBR图显示了分水岭和黄斑的最高信号强度。结论：宽场LSFG图显示了脉络膜后眼底的脉络膜血流动力学变化。灰度复合图显示细小的脉络膜血管，其分辨率与IA相当。脉络膜静脉分支网状血管显示脉搏与脉络膜血管同步。广野LSFG显示黄斑区脉络膜血流最高，并存在分水岭。
Purpose: To compare the images of choroidal vasculature obtained by laser speckle flowgraphy (LSFG) and indocyanine green angiography (IA), and to evaluate the imaging of choroidal hemodynamics in eyes with polypoidal choroidal vasculopathy (PCV) using LSFG.Methods: We performed IA and wide-field LSFG, which measures the index of blood velocity (mean square blur rate; MBR) in 25 eyes with PCV. We constructed an MBR map of the sequential MBR images (600 x 280 pixels) from four or five pulsations during measurement (4.5 s). A grayscale composite map of a still image was obtained by averaging the cumulative sum of the MBR map. We compared the angiographic images of the grayscale composite map to IA results and evaluated the choroidal hemodynamics of 25 eyes with PCV in the MBR map.Results: The choroidal vasculature on the grayscale map had a resolution similar to the IA results. The grayscale map detected branching network vessels in 20 (80%) of the 25 eyes and polypoidal lesions in 11 (44%) eyes. The MBR map showed that the pulsations of the branching network vessels and polypoidal lesions were synchronized with the cardiac rhythm. The fluctuation rates of the PCV lesions during one pulsation ranged from 8.3% to 26.7% (mean, 13.6%) and from 7.3% to 24.6% (mean, 15.9%) for the intact choroid. The MBR map showed the watershed zone and highest signal intensity in the macula.Conclusions: Using an MBR map, wide-field LSFG revealed the pulsating choroidal hemodynamics of the posterior fundus. A grayscale composite map showed the fine choroidal vasculature whose resolution was comparable to that of IA. The branching network vessels of PCV showed that pulsation was synchronized with the choroidal vessels. Wide-field LSFG showed the highest choroidal blood flow in the macular area and the presence of a watershed zone.