EEG-fMRI of idiopathic and secondarily generalized epilepsies
EEG-fMRI of idiopathic and secondarily generalized epilepsies
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DOI：
10.1016/j.neuroimage.2006.02.016
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发表时间：
2006-07-15
期刊：
影响因子：
5.7
通讯作者：
Lemieux, Louis
中科院分区：
文献类型：
--
作者：
Hamandi, Khalid;Salek-Haddadi, Afraim;Lemieux, Louis
我们采用同步脑电图和功能磁共振成像（EEG-fMRI）研究了特发性和继发性全身性癫痫（SGE）的全身性棘波活动（GSW）。最近的研究表明，丘脑和皮层的功能磁共振成像信号的变化与GSW在特发性全身性癫痫（IGE）。我们报告了一个大型队列的患者，包括IGE和SGE，并给出了我们的研究结果的功能解释。对46例GSW患者进行了EEG-fMRI研究，其中30例采用IGE，16例采用SGE。在EEG功能磁共振成像中，36例GSW患者中有25例出现GSW相关BOLD信号变化。这见于丘脑（60%），对称地见于额叶皮质（92%）、顶叶皮质（76%）和后扣带回皮质/楔前叶（80%）。丘脑BOLD变化主要为阳性，皮质变化主要为阴性。组分析显示IGE组皮质BOLD反应呈阴性，丘脑反应呈阳性，但程度较轻。丘脑激活与其在GSW中的已知作用一致，其在个别病例中的EEG-fMRI检测可能部分与记录的GSW时期的数量和持续时间有关。在IGE和SGE中，GSW引起的皮层fMRI反应的空间分布涉及在有意识休息期间最活跃的关联皮层区域。GSW期间这些区域的活动减少与失神发作的临床表现一致。(c)2006年爱思唯尔公司All rights reserved.
We used simultaneous EEG and functional MRI (EEG-fMRI) to study generalized spike wave activity (GSW) in idiopathic and secondary generalized epilepsy (SGE). Recent studies have demonstrated thalamic and cortical fMRI signal changes in association with GSW in idiopathic generalized epilepsy (IGE). We report on a large cohort of patients that included both IGE and SGE, and give a functional interpretation of our findings. Forty-six patients with GSW were studied with EEG-fMRI; 30 with IGE and 16 with SGE. GSW-related BOLD signal changes were seen in 25 of 36 individual patients who had GSW during EEG-fMRI. This was seen in thalamus (60%) and symmetrically in frontal cortex (92%), parietal cortex (76%), and posterior cingulate cortex/precuneus (80%). Thalamic BOLD changes were predominantly positive and cortical changes predominantly negative. Group analysis showed a negative BOLD response in the cortex in the IGE group and to a lesser extent a positive response in thalamus. Thalamic activation was consistent with its known role in GSW, and its detection in individual cases with EEG-fMRI may in part be related to the number and duration of GSW epochs recorded. The spatial distribution of the cortical fMRI response to GSW in both IGE and SGE involved areas of association cortex that are most active during conscious rest. Reduction of activity in these regions during GSW is consistent with the clinical manifestation of absence seizures. (c) 2006 Elsevier Inc. All rights reserved.