Serum renalase is related to catecholamine levels and renal function
Serum renalase is related to catecholamine levels and renal function
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血清肾酶与儿茶酚胺水平和肾功能有关
DOI：
10.1007/s10157-014-0951-8
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发表时间：
2015-02-01
影响因子：
2.3
通讯作者：
Wang, Niansong
中科院分区：
文献类型：
--
作者：
Wang, Feng;Li, Junhui;Wang, Niansong
研究背景肾酶是一种源自肾脏的单胺氧化酶，可以降解儿茶酚胺并调节血压和心血管功能。尽管已有研究表明血清肾酶水平随肾功能受损而显着降低,但尚不清楚其水平是否与患者不同阶段的慢性肾脏病(CKD)有关。方法选取87例CKD患者作为研究对象,采用ELISA法探讨血清肾酶和儿茶酚胺(CA)水平及其与其他肾功能指标的关系。结果血清肾酶水平及肾酶与儿茶酚胺(R/C)比值显着升高CKD 3-5期患者（217.4±103.8ng/L，1.00±0.21）高于CKD 1-2期患者（162.1±40.1ng/L，0.82±0.16；P<0.05），而CKD 1-2期患者与正常对照组之间无显着差异（167.8 ± 69.4 ng/L，0.88 ± 0.17；P> 0.05）。肾酶水平与儿茶酚胺水平呈线性相关（R2=0.817；P<0.01）。血清肾酶水平与收缩压（SBP）、血清CA、BUN、SCr、UA和CKD分期呈正相关（P<0.05），与RBC、Hb和估计GFR（eGFR）呈负相关（P<0.05）。 R/C比值与SBP、舒张压、BUN、SCr、UA、胱抑素C、β2微球蛋白、视黄醇结合蛋白4、CKD分期呈正相关（P<0.05），与RBC、Hb、eGFR、GFR呈负相关（P<0.05）。结论血清肾酶水平与CA高度相关，血清肾酶水平和R/C比值均与CA高度相关。与肾功能有关。
BackgroundRenalase is a kidney-origin monoamine oxidase which can degrade catecholamines and regulate blood pressure and cardiovascular function. Although it has been shown that serum renalase level significantly decreases with impaired renal function, it is not clear whether its level is related to different stages of chronic kidney disease (CKD) in patients.MethodsEighty-seven patients with CKD were selected as subjects of this study to investigate the serum renalase and catecholamine (CA) levels by ELISA method, and their relationship with other renal function indicators.ResultsSerum levels of renalase and renalase–catecholamine (R/C) ratios were significantly higher in CKD stage 3–5 patients (217.4 ± 103.8 ng/L, 1.00 ± 0.21) than CKD stage 1–2 patients (162.1 ± 40.1 ng/L, 0.82 ± 0.16;P< 0.05), while there was no significant difference between CKD stage 1–2 patients and the normal control group (167.8 ± 69.4 ng/L, 0.88 ± 0.17;P> 0.05). Renalase levels were linearly correlated with catecholamine levels (R2= 0.817;P< 0.01). Serum renalase levels were positively correlated with systolic blood pressure (SBP), serum CA, BUN, SCr, UA, and CKD stage (P< 0.05), while negatively correlated with RBC, Hb and estimated GFR (eGFR) (P< 0.05). R/C ratio was positively correlated with SBP, diastolic blood pressure, BUN, SCr, UA, cystatin C, β2 microglobulin, retinol binding protein-4 and CKD stage (P< 0.05), while negatively correlated with RBC, Hb, eGFR and GFR (P< 0.05).ConclusionsSerum levels of renalase are highly correlated with CA and both serum renalase levels and R/C ratios are related to renal function.