Integrin requirement for hippocampal synaptic plasticity and spatial memory
Integrin requirement for hippocampal synaptic plasticity and spatial memory
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DOI：
10.1523/jneurosci.23-18-07107.2003
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发表时间：
2003-08-06
影响因子：
5.3
通讯作者：
Davis, RL
中科院分区：
文献类型：
--
作者：
Chan, CS;Weeber, EJ;Davis, RL
记忆的建立需要中枢神经系统中突触前和突触后终末之间协调的信号传导。整联蛋白构成细胞粘附受体的大家族，已知其介导细胞之间或细胞与其外部环境之间的双向信号传导。我们在这里展示了许多不同的整合素，包括α 3和α 5，在成年小鼠大脑中广泛表达，并与突触相关。α 3整合素基因表达降低的小鼠不能维持海马CA1区神经元产生的长时程增强（LTP）。α 3和α 5整合素表达减少的小鼠表现出配对脉冲易化缺陷。α 3、α 5和α 8表达减少的小鼠在海马LTP和水迷宫中的空间记忆方面有缺陷，但具有正常的恐惧条件反射。这些结果表明，几种不同的整联蛋白参与了生理可塑性，并提供了它们对脊椎动物行为可塑性要求的第一个证据。
The establishment of memory requires coordinated signaling between presynaptic and postsynaptic terminals in the CNS. The integrins make up a large family of cell adhesion receptors that are known to mediate bidirectional signaling between cells or between cells and their external environment. We show here that many different integrins, including alpha3 and alpha5, are expressed broadly in the adult mouse brain and are associated with synapses. Mice with genetically reduced expression of alpha3 integrin fail to maintain long-term potentiation (LTP) generated in hippocampal CA1 neurons. Mice with reduced expression of the alpha3 and alpha5 integrins exhibit a defect in paired-pulse facilitation. Mice with reduced expression of alpha3, alpha5, and alpha8 are defective in hippocampal LTP and spatial memory in the water maze but have normal fear conditioning. These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates.