Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome
Reciprocal Regulation of 11β-HSDs May Predict Steroid Sensitivity in Childhood Nephrotic Syndrome
复制标题
11β-HSD 的相互调节可预测儿童肾病综合征的类固醇敏感性
DOI：
10.1542/peds.2015-4011
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发表时间：
2016
期刊：
影响因子：
8
通讯作者：
T. Hongo
中科院分区：
文献类型：
--
作者：
Shuji Sai;Masaki Yamamoto;R. Yamaguchi;K. Chapman;T. Hongo
儿童肾病综合征是一种类固醇依赖性与类固醇耐药同时发生的疾病，需要积极治疗以防止复发。迫切需要可用于分层治疗的预测生物标志物。在此，我们报告说，糖皮质激素代谢酶（1 型和 2 型 11β-羟基类固醇脱氢酶）的相互调节与儿童肾病综合征的类固醇反应和疾病缓解相关，这可能为识别需要积极治疗的患者提供标记。
Childhood nephrotic syndrome, in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase types 1 and 2, is associated with steroid-responsiveness and disease remission in childhood nephrotic syndrome, potentially providing a marker to identify patients in which aggressive therapy is required.