Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis.
Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis.
复制标题
尽管氢氯噻嗪诱导尿钠排泄，但选择性氯化物负荷对易发生中风的自发性高血压大鼠仍具有升压作用。
DOI：
10.1097/hjh.0b013e3283316cfc
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发表时间：
2010
影响因子：
4.9
通讯作者：
MorrisJr,RCurtis
中科院分区：
文献类型：
--
作者：
Schmidlin,Olga;Tanaka,Masae;Sebastian,Anthony;MorrisJr,RCurtis
ObjectiveTo test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance.MethodsIn 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the effects on telemetrically measured SBP of hydrochlorothiazide, 25 mg/kg per day, alone (‘TZ’, n= 11); hydrochlorothiazide combined with either KCl (‘KCLTZ’, 2% K+, n= 10) or KHCO 3 (‘KBCTZ’, 2% K+, n= 11) and no hydrochlorothiazide (‘CTL’, n= 11) over a 10-week period starting at 10 weeks of age.ResultsWith either TZ or KBCTZ, SBP did not increase above baseline values. However, KCLTZ induced a sustained increase in SBP of 17 mmHg (P< 0.0001), an increase almost half of that occurring without hydrochlorothiazide (CTL), 38 mmHg (P< 0.0001). Such divergence of blood pressures with KCLTZ and KBCTZ began over the first 3 days of their administration, even while they induced similarly negative external sodium balances, a positive one occurring only in CTL. Body weight increased more without, than with, hydrochlorothiazide, but did not differ between KCLTZ and KBCTZ. Changes in SBP occurring on day 2 after treatment assignment predicted final changes.ConclusionThese results demonstrate that in the SHRSP, dietary KCl loading can induce a pressor effect despite concomitant hydrochlorothiazide-induced natriuresis that elicits a negative external sodium balance. The results provide evidence that in the SHRSP the pressor effect of selective chloride loading does not depend on a positive external sodium balance, but rather on a mechanism actuated by chloride per se.
