Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation
Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation
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DOI：
10.1097/00043426-200401000-00003
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发表时间：
2004-01-01
影响因子：
1.2
通讯作者：
Cheng, SN
中科院分区：
文献类型：
--
作者：
Chen, CJ;Chao, TY;Cheng, SN
作者用骨髓移植治疗了一个6个月大的患有恶性婴儿骨质疏松症的男孩。将患者的临床反应与骨代谢标志物（如抗酒石酸酸性磷酸酶5b （TRAcP 5b）和骨特异性碱性磷酸酶（BAP））的生化反应进行比较。治疗成功，导致血清TRAcP 5b水平下降。这些骨特异性标记物可能对干细胞移植的恶性婴儿骨性硬化症患者的早期评估有用。
The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.