Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels.
Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels.
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小鼠气道的过敏原暴露会引起支气管和大肺血管的重塑。
DOI：
10.1164/rccm.200406-698oc
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发表时间：
2005
影响因子：
24.7
通讯作者：
J. Erjefält
中科院分区：
文献类型：
--
作者：
Kristina Rydell Törmänen;L. Uller;C. Persson;J. Erjefält
呼吸道结构重塑是过敏性呼吸道炎症的一个有文献记载的特征。为探讨支气管重塑是否与邻近肺血管重塑有关，致敏小鼠反复吸入卵清蛋白，并对支气管和肺血管进行组织学分析。过敏原攻击可引起支气管周围和血管周围嗜酸性粒细胞增多。在气管整装准备中研究的全身呼吸道微循环重塑，揭示了过敏原诱导的气道微血管直径和长度的增加。α-平滑肌肌动蛋白免疫染色显示，支气管和大肺血管中的平滑肌质量均增加。肺血管和支气管均可见I型前胶原和III型前胶原的表达增强。增殖细胞核抗原染色显示肺血管内皮细胞、肺血管内皮细胞和血管内皮细胞增殖增强。我们的结论是，发生在过敏原暴露的呼吸道中的重塑的中心特征也存在于肺血管中。这一发现在疾病的发生、病理生理学重要性和涉及的机制方面的意义值得进一步研究。
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate whether bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels were subjected to histologic analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both the diameter and length of the airway microvessels. Immunostaining for alpha-smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and procollagen III. Staining for proliferating cell nuclear antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling that take place in allergen-exposed airways are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation.
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DOI：
10.1165/ajrcmb.17.3.2733
发表时间：
1997-09-01
影响因子：
6.4
作者：
Minshall, EM;Leung, DYM;Hamid, Q
通讯作者：
Hamid, Q
DOI：
10.1152/ajplung.00324.2001
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2002-07-01
影响因子：
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McIntyre, TM
DOI：
10.1164/ajrccm.165.1.2105051
发表时间：
2002-01-01
影响因子：
24.7
作者：
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通讯作者：
Chi, EY
DOI：
10.1152/ajplung.00260.2002
发表时间：
2003-01-01
影响因子：
4.9
作者：
Justice, JP;Borchers, MT;Lee, JJ
通讯作者：
Lee, JJ