Evaluation of the Macular Choroidal Thickness Using Spectral Optical Coherence Tomography in Pseudoexfoliation Glaucoma
Evaluation of the Macular Choroidal Thickness Using Spectral Optical Coherence Tomography in Pseudoexfoliation Glaucoma
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DOI：
10.1097/ijg.0000000000000100
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发表时间：
2016-02-01
影响因子：
2
通讯作者：
Can, Izzet
中科院分区：
文献类型：
--
作者：
Bayhan, Hasan A.;Bayhan, Seray Aslan;Can, Izzet
目的：采用光谱光学相干断层扫描（SD-OCT）技术对假性剥脱性（PEX）青光眼患者32例（32只眼）和年龄匹配的健康对照者30例（30只眼）的脉络膜厚度（CT）进行评估。使用SD-OCT（RTVue-100）测量垂直于（从高反射视网膜色素上皮的外缘到内巩膜）中心凹、距中心凹1.5 mm颞侧、3.0 mm颞侧、1.5 mm鼻侧和3.0 mm鼻侧的CT值。鼻侧距中心凹1.5mm处的CT测量值分别为182.12 ± 39.88和201.56 ± 32.00 μ m（P = 0.039），在鼻侧距中央凹3.0 mm处，PEX青光眼组和对照组分别为126.47 +/- 32.12和146.60 +/- 31.37 μ m（P = 0.015）。两组患者的中心凹下和颞侧CT测量值无显著性差异（均P > 0.05）。结论：本研究的结果表明，PEX青光眼导致鼻侧脉络膜明显变薄。因此，用SD-OCT测量CT可能是更好地阐明PEX与青光眼视神经病变之间关系的方法。
Purpose: To evaluate the choroidal thickness (CT) in pseudoexfoliative (PEX) glaucoma and age-matched healthy subjects using spectral optical coherence tomography (SD-OCT).Patients and Methods: In this prospective study, 32 eyes of 32 PEX glaucoma patients and 30 eyes of 30 age-matched healthy subjects were enrolled. The CT is measured perpendicularly (from the outer edge of the hyperreflective retinal pigment epithelium to the inner sclera) at the fovea, and 1.5 mm temporal, 3.0 mm temporal, 1.5 mm nasal, and 3.0 mm nasal to the fovea using SD-OCT (RTVue-100).Results: The groups were similar regarding the mean age and axial length values (both, P > 0.05). The CT measurements were 182.12 +/- 39.88 and 201.56 +/- 32.00 mu m at 1.5 mm nasal to the fovea (P = 0.039), and 126.47 +/- 32.12 and 146.60 +/- 31.37 mu m at 3.0 mm nasal to the fovea (P = 0.015) in the PEX glaucoma and control groups, respectively. There were no significant differences in the subfoveal and temporal CT measurements among the 2 groups (all, P > 0.05).Conclusions: The findings of this study indicate that PEX glaucoma causes significant thinning in the nasal choroid. Thus, measuring the CT with SD-OCT may be the way of better clarification of the relationship between PEX and glaucomatous optic neuropathy.