Reactivation of recall-induced neurons contributes to remote fear memory attenuation
Reactivation of recall-induced neurons contributes to remote fear memory attenuation
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DOI：
10.1126/science.aas9875
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发表时间：
2018-06-15
期刊：
影响因子：
56.9
通讯作者：
Graff, Johannes
中科院分区：
文献类型：
--
作者：
Khalaf, Ossama;Resch, Siegfried;Graff, Johannes
恐惧减弱是通过用新的安全记忆痕迹抑制原始恐惧记忆痕迹来介导的，还是通过将原始恐惧痕迹更新为安全来介导的，这一直是神经科学和心理学中长期存在的问题。特别是，这两种情况中的哪一种是远程（一个月前）恐惧记忆减弱的基础，我们完全不知道，尽管在持久创伤的背景下有动力更好地理解这一过程。我们通过化学遗传学和印迹特异性方式发现，有效的远程恐惧减弱伴随着齿状回中记忆回忆诱导的神经元的重新激活，并且这些神经元的持续活动对于减少恐惧至关重要。这表明恐惧的原始记忆痕迹积极有助于远程恐惧的衰减。
Whether fear attenuation is mediated by inhibition of the original memory trace of fear with a new memory trace of safety or by updating of the original fear trace toward safety has been a long-standing question in neuroscience and psychology alike. In particular, which of the two scenarios underlies the attenuation of remote (month-old) fear memories is completely unknown, despite the impetus to better understand this process against the backdrop of enduring traumata. We found-chemogenetically and in an engram-specific manner-that effective remote fear attenuation is accompanied by the reactivation of memory recall-induced neurons in the dentate gyrus and that the continued activity of these neurons is critical for fear reduction. This suggests that the original memory trace of fear actively contributes to remote fear attenuation.