LINC00673 rs11655237 C>T and susceptibility to Wilms tumor: A five-center case-control study
LINC00673 rs11655237 C>T and susceptibility to Wilms tumor: A five-center case-control study
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LINC00673 rs11655237 C>T 与肾母细胞瘤的易感性：五中心病例对照研究
DOI：
10.1002/jgm.3133
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发表时间：
2019-12-16
影响因子：
3.5
通讯作者：
He, Jing
中科院分区：
文献类型：
--
作者：
Li, Suhong;Lin, Ao;He, Jing
研究背景肾母细胞瘤起源于胚胎肾间质，是一种常见的儿童肾癌。然而，关于LINC 00673多态性与肾母细胞瘤风险之间关联的流行病学数据很少。本病例对照研究旨在探讨LINC 00673 rs 11655237 C>T多态性在肾母细胞瘤易感性中的潜在作用。方法采用LINC 00673 rs 11655237 C>T基因分型技术，对中国5所医院414例患者和1199例对照进行基因分型。通过多元逻辑回归模型估计合并优势比（OR）和95%置信区间（CI），以确定LINC 00673 rs 11655237 C>T多态性与肾母细胞瘤易感性的相关性。结果LINC 00673基因rs 11655237 C>T多态性与肾母细胞瘤风险无显著相关性（CT对比CC：校正OR = 0.90，95% CI = 0.71-1.15; TT对比CC：校正OR = 0.86，95% CI = 0.50-1.49; TT/CT对比CC：校正OR = 0.90，95%CI = 0.71-1.13; TT与CC/CT：校正OR = 0.89，95%CI = 0.52-1.53）。在分层分析中，我们也没有发现这种基因型的任何显著结果。结论LINC 00673基因rs 11655237 C>T多态性与肾母细胞瘤易感性无关。这些数据可能有助于加强我们对LINC 00673 rs 11655237 C>T对Wilms肿瘤易感性的潜在贡献的理解。
Background Wilms tumor, a frequently occurring pediatric renal cancer worldwide, originated from the embryonal nephric mesenchyme. However, epidemiological data on the association between LINC00673 polymorphisms and Wilms tumor risk are scant. This case-control study was conducted to investigate the potential role of the LINC00673 rs11655237 C>T polymorphism in the susceptibility to Wilms tumor. Methods In the present study, we conducted a genotyping analysis of LINC00673 rs11655237 C>T in 414 cases and 1199 controls recruited from five hospitals in China. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models to determine the association of LINC00673 rs11655237 C>T polymorphism and Wilms tumor susceptibility. Results No significant association between the LINC00673 rs11655237 C>T polymorphism and Wilms tumor risk was observed (CT versus CC: adjusted OR = 0.90, 95% CI = 0.71-1.15; TT versus CC: adjusted OR = 0.86, 95% CI = 0.50-1.49; TT/CT versus CC: adjusted OR = 0.90, 95% CI = 0.71-1.13; and TT versus CC/CT: adjusted OR = 0.89, 95% CI = 0.52-1.53). We also failed to make any remarkable findings for this genotype in the stratification analysis. Conclusions In summary, we failed to provide any evidence in favor of the significant susceptibility of rs11655237 C>T polymorphism in LINC00673 to Wilms tumor. These data could be useful for reinforcing our understanding of the potential contribution of LINC00673 rs11655237 C>T to Wilms tumor susceptibility.