Multiple Sclerosis Performance Test: validation of self-administered neuroperformance modules
Multiple Sclerosis Performance Test: validation of self-administered neuroperformance modules
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DOI：
10.1111/ene.14162
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发表时间：
2020-03-02
影响因子：
5.1
通讯作者：
Rudick, R. A.
中科院分区：
文献类型：
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作者：
Rao, S. M.;Galioto, R.;Rudick, R. A.
背以 MSPT 认知测试（处理速度测试，PST）为例，引入基于回归的规范的概念来帮助临床解释表现分数。方法子研究 1 在 30 名 MS 患者和 30 名健康对照中评估了 CST、MDT 和 WST 的重测信度、实践效果和收敛效度。子研究 2 检查了 600 多名 MS 患者对 MS 残疾的敏感性，作为常规临床评估的一部分。子研究 3 比较了研究志愿者和临床样本的 PST 表现。结果 CST、MDT 和 WST 被证明是可靠、有效且对 MS 结果敏感的。性能与技术人员管理的测试相当。与研究志愿者样本相比，临床样本中的 PST 表现较差。 结论 自我管理的 MSPT 神经表现模块产生可靠、客观的指标，可用于临床实践并支持结果研究。已发表的需要患者自愿同意的研究可能会低估临床环境中观察到的认知功能障碍的发生率。
Background and purpose The purpose was to determine the test-retest reliability, practice effects, convergent validity and sensitivity to multiple sclerosis (MS) disability of neuroperformance subtests from the patient self-administered Multiple Sclerosis Performance Test (MSPT) designed to assess low contrast vision (Contrast Sensitivity Test, CST), upper extremity motor function (Manual Dexterity Test, MDT) and lower extremity motor function (Walking Speed Test, WST) and to introduce the concept of regression-based norms to aid clinical interpretation of performance scores using the MSPT cognition test (Processing Speed Test, PST) as an example.Methods Substudy 1 assessed test-retest reliability, practice effects and convergent validity of the CST, MDT and WST in 30 MS patients and 30 healthy controls. Substudy 2 examined sensitivity to MS disability in over 600 MS patients as part of their routine clinic assessment. Substudy 3 compared performance on the PST in research volunteers and clinical samples.Results The CST, MDT and WST were shown to be reliable, valid and sensitive to MS outcomes. Performance was comparable to technician-administered testing. PST performance was poorer in the clinical sample compared with the research volunteer sample.Conclusions The self-administered MSPT neuroperformance modules produce reliable, objective metrics that can be used in clinical practice and support outcomes research. Published studies which require patient voluntary consent may underestimate the rate of cognitive dysfunction observed in a clinical setting.