T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of Hantavirus Pulmonary Syndrome
T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of Hantavirus Pulmonary Syndrome
复制标题
叙利亚仓鼠汉坦病毒肺综合征模型的发病过程不需要 T 细胞
DOI：
10.1128/jvi.05356-11
复制
发表时间：
2011-10-01
影响因子：
5.4
通讯作者：
Hooper, Jay W.
中科院分区：
文献类型：
--
作者：
Hammerbeck, Christopher D.;Hooper, Jay W.
安第斯山脉病毒（ANDV）与人类中称为汉坦病毒肺综合征（HPS）的致死性血管渗漏综合征相关。在仓鼠中，ANDV引起与人类HPS非常相似的呼吸窘迫综合征。与HPS相关的大量血管渗漏的机制知之甚少;然而，T细胞免疫病理学已被牵连的间接和推论证据的基础上。在这里，我们表明，ANDV攻击后，仓鼠T细胞活化与疾病的发作相对应。然而，尽管T细胞数量显著减少，但环磷酰胺或特异性T细胞耗竭治疗不会影响疾病进程或改变存活动物的数量。这些数据首次证明，在人类HPS的仓鼠模型中，汉坦病毒的发病机制不需要T细胞。叙利亚仓鼠的T细胞耗竭对疾病进展的早期事件没有显著影响。此外，这些数据认为汉坦病毒诱导的血管通透性的机制，不涉及T细胞免疫病理学。
Andes virus (ANDV) is associated with a lethal vascular leak syndrome in humans termed hantavirus pulmonary syndrome (HPS). In hamsters, ANDV causes a respiratory distress syndrome closely resembling human HPS. The mechanism for the massive vascular leakage associated with HPS is poorly understood; however, T cell immunopathology has been implicated on the basis of circumstantial and corollary evidence. Here, we show that following ANDV challenge, hamster T cell activation corresponds with the onset of disease. However, treatment with cyclophosphamide or specific T cell depletion does not impact the course of disease or alter the number of surviving animals, despite significant reductions in T cell number. These data demonstrate, for the first time, that T cells are not required for hantavirus pathogenesis in the hamster model of human HPS. Depletion of T cells from Syrian hamsters did not significantly influence early events in disease progression. Moreover, these data argue for a mechanism of hantavirus-induced vascular permeability that does not involve T cell immunopathology.