Testosterone and dementia: too much ado about too little data.
Testosterone and dementia: too much ado about too little data.
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DOI：
10.1258/136218003100322323
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发表时间：
2003-09-01
期刊：
影响因子：
--
通讯作者：
Flicker, Leon
中科院分区：
文献类型：
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作者：
Almeida, Osvaldo P;Flicker, Leon
体外和动物研究表明，睾酮具有神经保护作用，并降低β-淀粉样蛋白和tau磷酸化的水平（这被认为是导致阿尔茨海默病（AD）发展的病理生理过程的关键）。这些发现表明，睾酮可能在调节认知功能和降低AD风险方面发挥重要作用。目前，睾酮与认知功能/AD之间相关性的临床证据来自于少量的横断面研究和5项针对健康老年男性的睾酮补充剂随机试验。结果表明，睾酮与视觉空间和记忆分数的关联很弱，但不同的研究结果并不一致，这些研究通常包括广泛的认知领域的多重比较。此外，AD患者的血清睾酮水平与对照组相当，大脑水平也是如此。总之，现有证据不支持睾酮与认知功能/AD之间存在强相关性。
In vitro and animal investigations have indicated that testosterone is neuroprotective and reduces the levels of beta-amyloid and the phosphorylation of tau (which are considered to be critical to the pathophysiological process that leads to the development of Alzheimer's disease (AD)). Such findings imply that testosterone may have an important role in the modulation of cognitive function and in reducing the risk of AD. Currently available clinical evidence of the association between testosterone and cognitive function/AD comes from a small number of cross-sectional studies and five randomised trials of testosterone supplementation for healthy older men. The results suggest that testosterone has a weak association with visuospatial and memory scores, but the findings are inconsistent across different studies, which often included multiple comparisons across a wide range of cognitive domains. In addition, the serum levels of testosterone in men with AD are comparable to those of controls, as are brain levels. In conclusion, currently available evidence does not support the existence of a strong association between testosterone and cognitive function/AD.