Poly[(N‐isopropylacrylamide)‐co‐(itaconic acid)] hydrogels with poly(ethylene glycol)
Poly[(N‐isopropylacrylamide)‐co‐(itaconic acid)] hydrogels with poly(ethylene glycol)
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DOI：
10.1002/pi.2717
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发表时间：
2010-02
影响因子：
3.2
通讯作者：
M. K. Krušić;S. Velickovic;P. Griffiths;J. Filipović
中科院分区：
文献类型：
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作者：
M. K. Krušić;S. Velickovic;P. Griffiths;J. Filipović
本文报道的工作目的是研究 N-异丙基丙烯酰胺 (NIPAM) 和衣康酸 (IA) 的温度和 pH 敏感水凝胶及其具有不同聚乙二醇 (PEG) 含量的半互穿聚合物网络 (semi-IPN)。研究了水凝胶和半互穿网络的刺激响应性、溶胀行为和机械性能，以研究不同用量的 PEG 的影响。进行脉冲梯度自旋回波核磁共振实验来研究扩散过程。 pH 敏感性随着半互穿网络中 PEG 含量的增加而增加，而总体吸水率受到扩散控制 (n < 0.5)。对于一定的 PEG 含量（5 和 10 wt%），半互穿网络表现出比聚（NIPAM-co-IA）共聚物更好的机械性能。水的自扩散系数的计算值表明，随着 PEG 量的增加，水在系统中的扩散变得容易，而模型化合物酒石酸美托洛尔的自扩散系数与 PEG 的量没有显着相关性。根据获得的结果并与文献报道的结果进行比较，所研究的半互穿网络可能在蛋白质和肽等大分子活性剂的控制释放方面具有潜在的应用。
The aim of the work reported here was to investigate temperature- and pH-sensitive hydrogels of N-isopropylacrylamide (NIPAM) and itaconic acid (IA) and their semi-interpenetrating polymer networks (semi-IPNs) with varying contents of poly(ethylene glycol) (PEG). The stimuli responsiveness, swelling behaviour and mechanical properties of the hydrogels and semi-IPNs were studied in order to investigate the effect of various amounts of PEG. Pulsed-gradient spin-echo NMR experiments were carried out to investigate the diffusion process. The pH sensitivity increased with an increasing amount of PEG in the semi-IPNs, while the overall rate of water uptake was diffusion-controlled (n < 0.5). For certain PEG contents (5 and 10 wt%), the semi-IPNs exhibited better mechanical properties than the poly(NIPAM-co-IA) copolymer. The calculated values of the self-diffusion coefficients of water indicated facilitated diffusion of water through the system with increased amounts of PEG, while the self-diffusion coefficients of a model compound, metoprolol tartrate, showed no significant dependence on the amount of PEG. According to the results obtained and compared to results reported in the literature, the investigated semi-IPNs may have potential applications in the controlled release of macromolecular active agents such as proteins and peptides.