Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites
Biocompatibility and chemical reaction kinetics of injectable, settable polyurethane/allograft bone biocomposites
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DOI：
10.1016/j.actbio.2012.07.037
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发表时间：
2012-12-01
影响因子：
9.7
通讯作者：
Guelcher, Scott A.
中科院分区：
文献类型：
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作者：
Page, Jonathan M.;Prieto, Edna M.;Guelcher, Scott A.
可注射和可固定的骨移植与预成型植入物相比具有显著的优势，因为它们能够使用微创技术进行管理，并符合缺损区的形状。然而，由于活性成分的潜在毒性和最终命运，可注射生物材料面临着生物相容性的挑战，这些活性成分没有被纳入最终固化的产品中。本研究考察了化学计量比和三乙二胺(TEDA)催化剂浓度对双组分赖氨酸衍生聚氨酯(PUR)生物复合材料的反应性、可注入性和生物相容性的影响。用原位衰减全反射傅里叶变换红外光谱技术测量了水(一种会产生气孔的发泡剂)、聚酯三醇、二丙醇(DPG)和同种异体骨颗粒与异氰酸酯端基预聚体的反应速率常数。根据测得的速率常数，建立了预测各组分随时间转化的动力学模型。尽管TEDA是一种著名的氨基甲酸酯胶凝催化剂，但它对与水的发泡反应的催化比为17：1。因此，动力学模型预测了预聚体和水进行了完全转化，而聚酯三醇和DPG的转化率为
Injectable and settable bone grafts offer significant advantages over pre-formed implants due to their ability to be administered using minimally invasive techniques and to conform to the shape of the defect. However, injectable biomaterials present biocompatibility challenges due to the potential toxicity and ultimate fate of reactive components that are not incorporated in the final cured product. In this study the effects of stoichiometry and triethylenediamine (TEDA) catalyst concentration on the reactivity, injectability, and biocompatibility of two component lysine-derived polyurethane (PUR) biocomposites were investigated. Rate constants were measured for the reactions of water (a blowing agent resulting in the generation of pores), polyester triol, dipropylene glycol (DPG), and allograft bone particles with the isocyanate-terminated prepolymer using an in situ attenuated total reflection Fourier transform infrared spectroscopy technique. Based on the measured rate constants, a kinetic model predicting the conversion of each component with time was developed. Despite the fact that TEDA is a well-known urethane gelling catalyst, it was found to preferentially catalyze the blowing reaction with water relative to the gelling reactions by a ratio >17:1. Thus the kinetic model predicted that the prepolymer and water proceeded to full conversion, while the conversions of polyester triol and DPG were