Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.
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DOI：
10.1016/j.cmet.2015.08.016
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发表时间：
2015-11-03
期刊：
影响因子：
29
通讯作者：
Iadecola C
中科院分区：
文献类型：
--
作者：
Ishii M;Iadecola C
阿尔茨海默病（AD）是一种复杂的神经退行性疾病，在认知功能下降之前几十年就开始了。虽然认知缺陷仍然是AD的主要表现，但也存在代谢和非认知异常，例如体重和神经内分泌功能的改变，通常在认知下降之前。此外，下丘脑功能障碍也可能是AD病理学的驱动因素。在这里，我们提供了一个简短的评估下丘脑功能障碍的AD，并提供了一个未被充分认识的双重作用下丘脑作为罪魁祸首和AD病理学的目标，以及到新的机会，治疗干预和生物标志物的发展。
Alzheimer’s disease (AD) is increasingly recognized as a complex neurodegenerative disease beginning decades prior to the cognitive decline. While cognitive deficits remain the cardinal manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in body weight and neuroendocrine functions are also present, often preceding the cognitive decline. Furthermore, hypothalamic dysfunction can also be a driver of AD pathology. Here we offer a brief appraisal of hypothalamic dysfunction in AD, and provide insight into an underappreciated dual role of the hypothalamus as both a culprit and target of AD pathology, as well as into new opportunities for therapeutic interventions and biomarker development.