Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA
Comparison of the effects of nebivolol and valsartan on BP reduction and sleep apnoea activity in patients with essential hypertension and OSA
复制标题
DOI：
10.1185/03007995.2010.497326
复制
发表时间：
2010-08-01
影响因子：
2.3
通讯作者：
Canisius, S.
中科院分区：
文献类型：
--
作者：
Heitmann, J.;Greulich, T.;Canisius, S.
目的：探讨第三代β受体阻滞剂奈比洛尔对轻至中度阻塞性睡眠呼吸暂停（OSA）高血压患者血压（BP）降低及多导睡眠图参数的影响。方法：在这项双盲、平行组研究中，患者在14天的安慰剂磨合期后，随机接受5毫克奈比洛尔或80毫克缬沙坦治疗，每天一次。在此期间，任何抗高血压药物都停止使用。在基线和治疗6周后进行血压和心率测量和夜间多导睡眠描记仪。评估了安全性和耐受性。结果：31例患者随机接受奈比洛尔（n = 16）或缬沙坦（n = 15）治疗。6周后，两种治疗均有效降低了收缩压和舒张压。两种药物之间血压的降低无统计学差异，但纳比洛尔的平均心率显著降低（与缬沙坦相比）
Objectives:To investigate the effect of nebivolol, a third generation beta-blocker, on blood pressure (BP) reduction and polysomnographic parameters in hypertensive patients with mild-to-moderate obstructive sleep apnoea (OSA).Methods:In this double-blind, parallel group study, patients were randomized to nebivolol 5 mg or valsartan 80 mg once daily following a 14-day, placebo run-in period during which any antihypertensive medication were discontinued. BP and heart rate measurements and overnight polysomnography were performed at baseline and after 6 weeks of treatment. Safety and tolerability were assessed.Results:Thirty-one patients were randomized to nebivolol (n = 16) or valsartan (n 15). After six weeks both systolic and diastolic BP were effectively reduced by both treatments. Reductions in BP were not statistically significant different between agents, but mean heart rate was significantly decreased with nebivolol (compared with valsartan (p