Idiopathic juxtafoveal retinal telangiectasis - New findings by ultrahigh-resolution optical coherence tomography
Idiopathic juxtafoveal retinal telangiectasis - New findings by ultrahigh-resolution optical coherence tomography
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DOI：
10.1016/j.ophtha.2005.08.016
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发表时间：
2006-01-01
期刊：
影响因子：
13.7
通讯作者：
Fujimoto, JG
中科院分区：
文献类型：
--
作者：
Paunescu, LA;Ko, TH;Fujimoto, JG
目的：研究超高分辨率光学相干断层扫描（UHR OCT）的能力;与市售OCT标准分辨率系统StratusOCT比较，用于特发性中心凹旁视网膜毛细血管扩张（IJT）的成像;并证明UHR OCT提供有关疾病形态、发病机制和治疗的额外信息。设计：回顾性、观察性、干预性病例系列。参与者：10例患者的19只眼至少有1只眼诊断为IJT。所有患者均在同一次访视时使用UHR OCT和StratusOCT成像。一部分患者在IJT治疗前后也进行了成像。主要结局指标：超高分辨率和标准分辨率横截面断层图像的IJT pathology.Results：使用标准和超高分辨率OCT，我们确定了以下特点的IJT：（1）OCT上的视网膜增厚和荧光素血管造影术上的渗漏之间缺乏相关性，（2）光感受器层的损失和破坏，（3）小凹中和内部视网膜层（例如内核层或神经节细胞层）内的囊状结构，（4）覆盖在小凹上的与潜在组织损失相关的独特的内部界膜，（5）中心凹附近的视网膜内新生血管;（6）中心视网膜内沉积物和斑块。在63%的情况下，异常血管和感光层的不连续性的存在与visual acuity.Conclusions：超高分辨率OCT提高了与IJT相关的视网膜病理学的可视化，并允许识别与之相关的新功能。
Objective: To investigate the capabilities of ultrahigh-resolution optical coherence tomography (UHR OCT); to compare with the commercially available OCT standard-resolution system, StratusOCT, for imaging of idiopathic juxtafoveal retinal telangiectasis (IJT); and to demonstrate that UHR OCT provides additional information on disease morphology, pathogenesis, and management.Design: Retrospective, observational, interventional case series.Participants: Nineteen eyes of 10 patients diagnosed with IJT in at least one eye.Method. All patients were imaged with UHR OCT and StratusOCT at the same visit. A subset of patients was also imaged before and after treatment of IJT. Main Outcome Measures: Ultrahigh- and standard-resolution cross-sectional tomograms of IJT pathology.Results: Using both standard- and ultrahigh-resolution OCT, we identified the following features of IJT: (1) a lack of correlation between retinal thickening on OCT and leakage on fluorescein angiography, (2) loss and disruption of the photoreceptor layer, (3) cystlike structures in the foveola and within internal retinal layers such as the inner nuclear or ganglion cell layers, (4) a unique internal limiting membrane draping across the foveola related to an underlying loss of tissue, (5) intraretinal neovascularization near the fovea, and (6) central intraretinal deposits and plaques. In 63% of cases, the presence of abnormal vessels and a discontinuity of the photoreceptor layer correlated with visual acuity.Conclusions: Ultrahigh-resolution OCT improves visualization of the retinal pathology associated with IJT and allows identification of new features associated with it. Some of these features, such as discontinuity of the photoreceptor layer, are revealed only by UHR OCT.