Validation of a computational model of cardiac defibrillation

Validation of a computational model of cardiac defibrillation
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心脏除颤计算模型的验证

DOI:
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发表时间:
2013
期刊:
Computers in cardiology
影响因子:
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通讯作者:
F. Fenton
F. Fenton
中科院分区:
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文献类型:
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作者:
Jean Bragard;J. Elorza;E. Cherry;F. Fenton

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我们开发并验证了用于研究除颤的心室颤动的三维模型。具体来说,我们使用一个兔子心室几何形状作为一个现实的模型系统,用于评估疗效的电击。从模拟中获得的数据进行了分析的剂量-反应曲线。与临床相关值一致,我们发现,在我们的模型中,约6.6 V/cm的电场强度表明12 ms双相电击成功除颤的概率为50%。我们验证的模型将是有用的,优化除颤协议和进行详细的研究除颤机制。
We develop and validate a three-dimensional model of ventricular fibrillation for use in studying defibrillation. Specifically, we use a rabbit ventricular geometry as a realistic model system for evaluating the efficacy of defibrillatory shocks. Data obtained from the simulations are analyzed in terms of a dose-response curve. In agreement with clinically relevant values, we find that an electric field strength of about 6.6 V/cm indicates a 50% probability of successful defibrillation for a 12-ms monophasic shock in our model. Our validated model will be useful for optimizing defibrillation protocols and for performing detailed studies of defibrillation mechanisms.
DOI: 10.1529/biophysj.104.043299
发表时间: 2004-09-01
影响因子: 3.4
作者:
Iyer, V;Mazhari, R;Winslow, RL
通讯作者: Winslow, RL
DOI: 10.1152/ajpheart.00747.2003
发表时间: 2004-06-01
影响因子: 4.8
作者:
Cherry, EM;Fenton, FH
通讯作者: Fenton, FH