Evaluation of immunomodulatory effects of nisin-containing diets on mice
Evaluation of immunomodulatory effects of nisin-containing diets on mice
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DOI：
10.1111/j.1574-695x.1999.tb01262.x
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发表时间：
1999-05-01
影响因子：
--
通讯作者：
López, GAD
中科院分区：
文献类型：
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作者：
de Pablo, MA;Gaforio, JJ;López, GAD
研究了乳酸链球菌素对小鼠免疫功能的影响。将Nisin(以商业制剂Nisaplin的形式)添加到喂养30、75或100天的实验小鼠的饮食中。短期服用含Nisaplin的饮食，可导致CD_4和CD_8 T淋巴细胞计数增加，B淋巴细胞计数减少。在长时间饮食后，T细胞计数恢复到对照水平。在长期服用较低(但不是较高)的尼萨普林浓度后，B淋巴细胞水平也达到了正常水平。长期服用含Nisaplin的饲料(100天)后，小鼠外周血巨噬细胞/单核细胞比例显著增加，且呈浓度依赖性。虽然饮食对小鼠的腹膜细胞数量没有影响，但长期服用低剂量(但不是高剂量)尼沙普林后，小鼠腹膜细胞的吞噬活性下降。(C)1999年欧洲微生物学会联合会。爱思唯尔科学公司出版。版权所有。
The effect of nisin on the immune response of mice was studied. Nisin (in the form of the commercial preparation Nisaplin) was incorporated in the diet of experimental mice which were Fed for 30, 75 or 100 days. Short-term administration of diets containing Nisaplin induced an increase of both CD4 and CD8 T-lymphocyte cell counts and also a decrease of B-lymphocyte counts. After prolonged diet administration, T-cell counts returned to control levels. Normal levels of B-lymphocytes were also reached after prolonged administration of the lower (but not the higher) Nisaplin concentration. The macrophage/monocyte fraction isolated from peripheral blood became significantly increased after long-term administration (100 days) of Nisaplin-containing diets in a concentration-dependent way. Although the number of peritoneal cells was not affected by the diets, the phagocytic activity of peritoneal cells decreased after prolonged administration of low (but not high) Nisaplin doses. (C) 1999 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.