Brain Oxygen Utilization Measured with 0- 15 Radiotracers and Positron Emission Tomography
Brain Oxygen Utilization Measured with 0- 15 Radiotracers and Positron Emission Tomography
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发表时间：
2006
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通讯作者：
M. Mintun;M. Raichle;W. Martin
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作者：
M. Mintun;M. Raichle;W. Martin
I23秒)进入身体的血管室，导致标记的氧气分布到组织，在那里它被转化为015标记的代谢水。标记的水然后通过相同的血管室重新分配到所有组织。未代谢的标记分子氧最终通过呼吸除去。氧-15示踪剂的这些特性已被纳入一个平衡模型，该模型已被用于测量人脑中的氧气消耗，使用从顺序吸入到[o -15]氧和二氧化碳平衡的数据（1,2）。该技术的重要缺点包括需要相对复杂的系统来持续输送
I23 sec) into the vascular compartment of the body re sults in the distribution of the labeled oxygen to the tissues, where it is converted to 015-labeled water of metabolism. The labeled water then redistributes to all tissues by way of the same vascular compartment. Un metabolized labeled molecular oxygen is ultimately re moved by respiration. Thesepropertiesof the oxygen-15 tracerhavebeen incorporated into an equilibrium model that has been used to measure oxygen consumption in the human brain using data from the sequential inhalation to equilibrium of [O-l5]oxygen and carbon dioxide (1,2). Important disadvantages of this technique include the relatively complex system required for constant delivery of the