Granular retrosplenial cortex layer 2/3 generates high-frequency oscillations dynamically coupled with hippocampal rhythms across brain states.
Granular retrosplenial cortex layer 2/3 generates high-frequency oscillations dynamically coupled with hippocampal rhythms across brain states.
复制标题
颗粒状压后皮质层 2/3 产生高频振荡，与跨大脑状态的海马节律动态耦合。
DOI：
10.1016/j.celrep.2024.113910
复制
发表时间：
2024
期刊：
影响因子：
8.8
通讯作者：
English,DanielFine
中科院分区：
文献类型：
--
作者：
Arndt,KaiserC;Gilbert,EarlT;Klaver,LianneMF;Kim,Jongwoon;Buhler,ChelseaM;Basso,JuliaC;McKenzie,Sam;English,DanielFine
颗粒状脾后皮层（gRSC）表现出高频振荡（HFOs; ~ 150 Hz），这可以由海马-耻骨下通路驱动。gRSC的细胞突触和层状组织如何促进hfo尚不清楚。在这里，我们使用焦点光遗传学和硅探针记录在行为小鼠中探测gRSC HFO的产生及其与海马节律的耦合。chr2介导的camkii表达细胞在L2/3或L5中激发诱导HFO，但自发HFO仅在L2/3中发现，HFO功率最高。在静止和θ波下降阶段，hfo与CA1尖锐波纹（SPW-Rs）耦合。对于SPW-Rs和θ振荡期间的事件，gRSC HFO电流源和汇是相同的。独立分量分析表明，CA1层空洞分子中的高γ (50 ~ 100 Hz)与HFO功率可调制。因此，在不同的大脑和行为状态下，hfo可能促进了gRSC、海马和内侧内嗅皮层之间的多突触环路的区域间交流。
The granular retrosplenial cortex (gRSC) exhibits high-frequency oscillations (HFOs; ∼150 Hz), which can be driven by a hippocampus-subiculum pathway. How the cellular-synaptic and laminar organization of gRSC facilitates HFOs is unknown. Here, we probe gRSC HFO generation and coupling with hippocampal rhythms using focal optogenetics and silicon-probe recordings in behaving mice. ChR2-mediated excitation of CaMKII-expressing cells in L2/3 or L5 induces HFOs, but spontaneous HFOs are found only in L2/3, where HFO power is highest. HFOs couple to CA1 sharp wave-ripples (SPW-Rs) during rest and the descending phase of theta. gRSC HFO current sources and sinks are the same for events during both SPW-Rs and theta oscillations. Independent component analysis shows that high gamma (50–100 Hz) in CA1 stratum lacunosum moleculare is comodulated with HFO power. HFOs may thus facilitate interregional communication of a multisynaptic loop between the gRSC, hippocampus, and medial entorhinal cortex during distinct brain and behavioral states.