Effects of six months of clozapine treatment on the quality of life of chronic schizophrenic patients.
Effects of six months of clozapine treatment on the quality of life of chronic schizophrenic patients.
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DOI：
10.1176/ps.41.8.892
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发表时间：
1990-08
期刊：
影响因子：
--
通讯作者：
H. Meltzer;S. Burnett;B. Bastani;L. Ramirez
中科院分区：
文献类型：
--
作者：
H. Meltzer;S. Burnett;B. Bastani;L. Ramirez
在一项开放试验中，前瞻性地研究了氯氮平治疗约6个月对38名难治性精神分裂症患者生活质量的影响。生活质量量表被用来提供患者心理社会功能变化的客观测量。该量表的所有四个因素都有显著改善。在基线和6个月时，这些评分与简明精神病评定量表的评分呈负相关。在12个月时，患者的再住院率降低了83%，并且独立于6个月的生活质量评级。
The effect of approximately six months of treatment with clozapine on the quality of life of 38 treatment-resistant schizophrenic patients was prospectively studied in an open trial. The Quality of Life Scale was used to provide an objective measure of changes in patients' psychosocial functioning. Significant improvement was noted on all four factors of the scale. The ratings tended to be negatively correlated with ratings on the Brief Psychiatric Rating Scale at baseline and at six months. At 12 months, patients' rehospitalization rate was reduced by 83 percent and was independent of the six-month quality-of-life ratings.