EFFECT OF ENERGY RESTRICTION ON TOTAL HEAT-PRODUCTION, BASAL METABOLIC-RATE, AND SPECIFIC DYNAMIC ACTION OF FOOD IN RATS
EFFECT OF ENERGY RESTRICTION ON TOTAL HEAT-PRODUCTION, BASAL METABOLIC-RATE, AND SPECIFIC DYNAMIC ACTION OF FOOD IN RATS
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DOI：
10.1093/jn/111.10.1691
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发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
NESHEIM, MC
中科院分区：
文献类型：
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作者：
FORSUM, E;HILLMAN, PE;NESHEIM, MC
人类和实验动物能够主要通过降低基础代谢率(BMR)来适应有限的能量摄入水平，而能量限制对食物的特定动态作用(SDA)和自发活动的影响还不是很清楚。生长大鼠在28-31天内随机喂养或限量饮食。然后用间接量热法测定每只大鼠22h内的总产热量(THP)和基础代谢率(BMR)，以及一顿试验餐的SDA。量热仪研究结束后，将大鼠饲养在代谢笼中6天，之后处死大鼠，并分析其总的身体成分。在研究的最后7天，老鼠的能量平衡是通过身体成分的变化和这段时间内食物摄入量的测量来计算的。在量热仪实验中，对大鼠的自发活动进行了间接估计。限制饲养大鼠的THP、BMR和SDA显著低于自由喂养大鼠。从身体成分测量来看，在热量测量和身体组成研究进行之前，与随意喂养的大鼠相比，在热量测量研究之前限制食物摄入量的大鼠动员了更多的蛋白质和更少的脂肪。两种饮食处理组小鼠自发活动无明显差异。
Man and experimental animals are able to adapt to restricted levels of energy intake mainly by a reduction in basal metabolic rate (BMR), while the effects of energy restriction on the specific dynamic action (SDA) of food and the spontaneous activity are less well established. Growing rats were fed ad lib or restricted amounts of diet during 28-31 days. Then total heat production (THP) and BMR during 22 h, as well as SDA of a test meal, were measured on individual rats by indirect calorimetry. After the calorimeter study rats were kept in metabolic cages for 6 days after which they were killed and analyzed for total body composition. The energy balance of the rats over the last 7 days of the study was calculated from changes in body composition and measurements of food intake during this period. During the calorimeter experiment an indirect estimation of the spontaneous activity of the rat was made. THP, BMR and SDA of restricted rats were significantly lower than for ad lib fed rats. From body composition measurements, rats restricted in food intake before the calorimetry study mobilized more protein and less fat compared to rats fed ad lib until the calorimetry and body composition studies were carried out. No difference in spontaneous activity was observed between the 2 dietary treatments.