Epigenetics in allergic diseases.
Epigenetics in allergic diseases.
复制标题
DOI：
10.1097/mop.0000000000000285
复制
发表时间：
2015-12
影响因子：
3.6
通讯作者：
Vercelli D
中科院分区：
文献类型：
--
作者：
DeVries A;Vercelli D
Allergic diseases are among the most prevalent chronic diseases of childhood, affecting more than 7 million children in the United States. Epidemiological evidence supports the idea that the inception of allergic diseases is typically before the pre-school years, even when chronic symptoms do not emerge until adulthood. The role of epigenetic mechanisms (particularly DNA methylation) in allergic disease is under active investigation because these mechanisms are known to be at the interface among gene regulation, environmental stimuli and developmental processes, all of which are essential for the pathogenesis for asthma and allergy. This article specifically reviews genome-wide DNA methylation studies in allergic disease. Differential DNA methylation at specific regions appears to be associated with concurrent allergic disease. A few studies have identified methylation signatures predictive of disease. DNA methylation signatures have been shown be associated with several allergic disease phenotypes, typically concurrently with disease. The few that have been found to precede diagnosis are especially interesting because they highlight an early trajectory to disease.
