Is feminization in alcoholic men due in part to portal hypertension: A rat model
Is feminization in alcoholic men due in part to portal hypertension: A rat model
复制标题
酗酒男性的女性化部分是由于门静脉高压所致：大鼠模型
DOI：
10.1016/0016-5085(80)90196-1
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发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
R. Lester
中科院分区：
文献类型：
--
作者：
D. Thiel;J. Gavaler;F. L. Slone;C. F. Cobb;William I. Smith;K. Bron;R. Lester
在酒精喂养和等热量喂养的对照大鼠中，测定了手术产生的门静脉高压对肝脏、脾脏、睾丸和精囊以及生化肝功能试验和血浆类固醇浓度的影响。无论饮食如何，部分门静脉结扎使门静脉压力加倍（P < 0.01）。肝（P < 0.05）和脾（P < 0.01）的重量与门静脉部分结扎组动物高于对照组，无论饮食。相比之下，结扎和非结扎动物之间的睾丸或前列腺和精囊重量没有差异，尽管与等热量对照组相比，酒精喂养动物的这些器官重量降低（P < 0.01）。酒精喂养降低血浆睾酮水平（P < 0.01）。增加部分门静脉结扎没有进一步降低血清睾酮水平。当与自由进食动物相比时，酒精进食和等热量对照动物中的皮质酮水平均增加（P < 0.01）。未观察到皮质酮进一步增加，加上部分门静脉结扎。在酒精喂养的动物中，血浆雌二醇水平降低（P < 0.05），与性腺萎缩的程度一致。随着门静脉部分结扎的增加，两个饮食组的雌二醇水平均升高（P < 0.01）。与自由对照组相比，在部分门静脉结扎之前，酒精喂养的动物和等热量对照组的血浆雌酮水平升高（P < 0.01），并且随着部分门静脉结扎而进一步升高。这些研究是一致的假设，门静脉高压症以及酒精诱导的肝脏疾病，本身是重要的慢性酒精男性女性化的发病机制。
The effect of surgically created portal hypertension on the liver, spleen, testes, and seminal vesicles and upon biochemical liver function tests and plasma steroid concentrations was determined in alcohol-fed and isocalorically fed control rats. Partial-portal vein ligation doubled the portal venous pressure (P < 0.01) regardless of diet. Hepatic (P < 0.05) and splenic weights (P < 0.01) of the animals with partial-portal vein ligation were greater than those of controls, regardless of diet. In contrast, no difference in testes or prostate and seminal vesicle weight was observed between ligated and nonligated animals although the weight of these organs was reduced (P < 0.01) in the alcohol-fed animals when compared to the isocaloric controls. Alcohol feeding reduced plasma testosterone levels (P < 0.01). The addition of partial-portal vein ligation did not further reduce serum levels of testosterone. Corticosterone levels were increased in both alcohol-fed and isocaloric control animals when compared to ad libitum fed animals (P < 0.01). No further increase in corticosterone was observed with the addition of partial-portal vein ligation. Plasma estradiol levels were reduced in the alcohol-fed animals (P < 0.05) consistent with the degree of gonadal atrophy present. With the addition of partial-portal vein ligation estradiol levels increased (P < 0.01) in both dietary groups. Compared to ad libitum controls, plasma estrone levels were increased (P < 0.01) in alcohol-fed animals and isocaloric controls before partial-portal vein ligation and increased further with partial-portal vein ligation. These studies are consistent with the hypothesis that portal hypertension as well as alcohol-induced liver disease, per se, are important in the pathogenesis of feminization of chronic alcoholic men.