Developmental precursors of child- and adolescent-onset schizophrenia and affective psychoses: diagnostic specificity and continuity with symptom dimensions
Developmental precursors of child- and adolescent-onset schizophrenia and affective psychoses: diagnostic specificity and continuity with symptom dimensions
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DOI：
10.1192/bjp.182.1.37
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发表时间：
2003-01-01
影响因子：
10.5
通讯作者：
Hollis, C
中科院分区：
文献类型：
--
作者：
Hollis, C
背景据报道，在儿童和成人精神分裂症和情感性精神病中，病前损害的发生率都有所增加。为了检验病前损害与儿童和精神分裂症发作之间的特定关联的证据，以及病前损害与精神病症状维度之间是否存在特定的连续性。对110例首发儿童和儿童期精神病（年龄10- 17岁）的回顾性病例研究。来自OPCRIT算法的DSM III-R诊断显示61例精神分裂症（平均年龄14.1岁）和49例其他非精神分裂症性精神病（平均年龄14.7岁）。早发性精神分裂症患者的病前社会功能障碍较其他早发性精神病患者多见（OR 1.9，P = 0.03）。总的来说，病前发育受损、精神病期间遗尿和尿失禁与阴性精神病症状维度特别相关。儿童和青少年精神分裂症患者发病前的社会功能障碍比其他精神病患者更明显.从病前损伤到阴性症状似乎有发展的连续性。利益声明。C. H.是由医学研究理事会资助的
Background. An increased rate of premorbid impairment has been reported in both child- and adolescent-onset schizophrenic and affective psychoses.Aims. To examine the evidence for a specific association between premorbid impairment and child- and adolescent-onset schizophrenia, and whether specific continuities exist between premorbid impairments and psychotic symptom dimensions.Method. Retrospective case note study of 110 first-episode child- and adolescent-onset psychoses (age 10- 17 years). DSM III-R diagnoses derived from the OPCRIT algorithm showed 61 with schizophrenia (mean age 14.1 years) and 49 with other non-schizophrenic psychoses (mean age 14.7 years).Results. Premorbid social impairment was more common in early-onset schizophrenia than in other early-onset psychoses (OR 1.9, P = 0.03). Overall, impaired premorbid development, enuresis and incontinence during psychosis were specifically associated with the, negative psychotic symptom dimension.Conclusions. Premorbid social impairments are more marked in child- and adolescent- onset schizophrenia than in other psychoses. There appears to be developmental continuity from premorbid impairment to negative symptoms.Declaration of interest. C. H. was funded by the Medical Research Council.