Reproductive outcomes in families of DBCP-exposed men.
Reproductive outcomes in families of DBCP-exposed men.
复制标题
暴露于 DBCP 的男性家庭的生殖结果。
DOI：
10.1080/00039896.1984.10545840
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. Israeli
中科院分区：
文献类型：
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作者：
J. Goldsmith;G. Potashnik;R. Israeli
在一个工厂，直到1977年，生产1，2-二溴-3-氯丙烷（DBCP），雇用了30名工人的家庭，已监测5年。1977年，13名无精子症男性在生产过程中的估计接触时间超过100小时;其中4人恢复了精子发生，2人生下了4个女婴。1977年有8名少精子症男性接受了34-95小时的照射;在随后由其妻子所生的8名子女中，6名为女性。1977年，估计暴露时间在10至60小时之间的5名男子精子正常，随后他们生下的5名儿童中，4名为男性，1名为女性。4名非接触男子和接触前接触男子的家庭的妊娠结果为27名男婴和24名女婴。接触过放射性物质的男性所生的妊娠中自然流产率没有增加。在未受辐射的孕妇所生婴儿中，有4名婴儿死亡，5名婴儿先天畸形。在这些男子接触后，其妻子所生的子女中没有婴儿或胎儿死亡，也没有先天性畸形。根据P = 0.015的二项概率，如果接触者的妻子有睾丸毒性证据，则其所生的12个婴儿中至少有10个是女性。接触工人家庭所生的孩子健康状况良好。观察到的女性性别优势的一个可能解释可能是Y染色体不分离，据Kapp等人报道，这种情况在DBCP工人的精子中更常见。
The families of 30 workers employed in a plant which, until 1977, had produced 1,2-dibromo-3-chloropropane (DBCP), have been monitored for 5 yr. Thirteen men who were azoospermic in 1977 had more than 100 hr of estimated exposure in production; of these, 4 have recovered spermatogenesis and 2 have fathered 4 female children. Eight men who were oligospermic in 1977 had been exposed for 34-95 hr; of 8 children subsequently born to their wives, 6 were female. Five men with exposure times estimated to be between 10 and 60 hr were normospermic in 1977, and of 5 children subsequently born to them, 4 were male and 1 was female. The outcome of the pregnancies among families of 4 non-exposed men and of exposed men prior to exposure resulted in 27 male and 24 female children. No increase in spontaneous abortion occurred in pregnancies fathered by exposed men. Four infant deaths and 5 congenital anomalies occurred among the babies born of unexposed pregnancies. No infant or fetal deaths and no congenital abnormalities occurred among children born to wives of men after the men were exposed. The birth of at least 10 females of 12 babies born to wives of exposed men with evidence of testicular toxicity would be expected according to binomial probabilities with a P = .015. The children born to families of exposed workers are in good health. A possible explanation for the observed female sex predominance might be Y chromosome non-disjunction, which was reported to be more frequent in sperm of DBCP workers by Kapp et al.