Incidence of nephrogenic systemic fibrosis at two large medical centers
Incidence of nephrogenic systemic fibrosis at two large medical centers
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DOI：
10.1148/radiol.2483071863
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发表时间：
2008-09-01
期刊：
影响因子：
19.7
通讯作者：
Valeri, Anthony M.
中科院分区：
文献类型：
--
作者：
Prince, Martin R.;Zhang, Honglei;Valeri, Anthony M.
目的：确定接受钆基造影剂（GBCA）增强磁共振（MR）成像的患者中肾源性系统性纤维化（NSF）的发病率和相关风险因素。材料和方法：获得了机构审查委员会的批准，对两家医院的病历进行回顾性审查，以确定1997年1月1日以来所有活检证实的NSF病例和所有接受GBCA的患者，到2007年6月30日。无需患者知情同意。NSF的发病率计算谁收到了标准剂量的GBCA的患者，谁收到了高剂量的患者，和亚组的肾功能不全的患者。所有患者的估计肾小球滤过率（eGFR）均低于30 mL/ min，11例患有急性肾功能衰竭或慢性肾功能衰竭急性恶化。74124例标准剂量GBCA患者中，在未进行肾功能筛查的情况下进行钆增强MRI后，NSF的发生率为0，8997例高剂量组中有15例（0.17%）发生NSF（P
Purpose: To determine the incidence and associated risk factors of nephrogenic systemic fibrosis (NSF) in patients who undergo gadolinium-based contrast agent (GBCA)-enhanced magnetic resonance (MR) imaging.Materials and Methods: Institutional review board approval was obtained for retrospective review of the medical records from two hospitals to identify all cases of biopsy-confirmed NSF and all patients administered a GBCA from January 1, 1997, to June 30, 2007. Informed patient consent was not required. The incidence of NSF was calculated for patients who received a standard dose of GBCA, patients who received a high dose, and subgroups of patients with renal impairment.Results: Fifteen patients developed NSF after gadolinium-enhanced MR imaging. All of them had an estimated glomerular filtration rate (eGFR) lower than 30 mL/ min, and 11 had acute renal failure or acute deterioration of chronic renal failure. The incidence of NSF after gadolinium-enhanced MR imaging without screening for renal function was zero of 74 124 patients with the standard dose of GBCA and 15 (0.17%) of 8997 patients with the high dose (P