A COMPARISON OF SURVIVAL, GROWTH, AND PULMONARY-FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS IN BOSTON AND TORONTO
A COMPARISON OF SURVIVAL, GROWTH, AND PULMONARY-FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS IN BOSTON AND TORONTO
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DOI：
10.1016/0895-4356(88)90063-7
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发表时间：
1988-01-01
影响因子：
7.2
通讯作者：
LEVISON, H
中科院分区：
文献类型：
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作者：
COREY, M;MCLAUGHLIN, FJ;LEVISON, H
对两个规模和年龄分布相似的囊性纤维化 (CF) 诊所人群的生长、肺功能和生存进行了比较。对波士顿的 499 名患者（平均 .+-. SD 年龄 15.9 .+-. 9.6，范围 1 个月至 45 岁）和多伦多的 534 名患者（平均 .+-. SD 年龄 15.2 .+-. 8.3，范围 1 个月至 43 岁）进行了身高和体重测量。波士顿组中男性占 57%，多伦多组中男性占 58%。 64% 的波士顿患者和 77% 的多伦多患者记录了肺功能测试结果。对 CF 患者登记处生成的 1972 年至 1981 年期间的生存曲线进行了比较。波士顿的患者往往比多伦多的患者矮。这种模式在 10-20 岁年龄组的男女中均可见。多伦多男性的体重也比波士顿男性重。波士顿和多伦多 CF 患者的一秒平均用力呼气量 (FEV1) 无论以预测百分比还是按年龄组的升数表示，均无差异。波士顿的中位生存年龄为 21 岁，多伦多为 30 岁，这两条曲线与 10 岁有显着差异。尽管进行性肺病是囊性纤维化死亡的主要原因，但这两个患者组的生长和生存差异以及年龄特异性肺功能非常相似，建议进一步检查 CF 的营养指导和干预，特别是在传统的饮食脂肪限制方面。
Two cystic fibrosis (CF) clinic populations of similar size and age distribution were compared with respect to growth, pulmonary function, and survival. Height and weight measurements were made on 499 patients in Boston (mean .+-. SD age 15.9 .+-. 9.6, range 1 month to 45 years) and on 534 patients in Toronto (mean .+-. SD age 15.2 .+-. 8.3, range 1 month to 43 years) Males constituted 57% in the Boston group, 58% in Toronto. Pulmonary function test results were recorded for 64% of the Boston patients and 77% of the Toronto patients. Survival curves for the period 1972-1981 generated by the CF Patient Registry were compared. Patients in Boston tended to be shorter than patients in Toronto. This pattern was seen in both sexes in the 10-20 year age groups. Toronto males also weighed more than Boston males. Mean forced expiratory volume in one second (FEV1) was not different in Boston and Toronto CF patients whether expressed as a percent of predicted or in litres by age groups. Median age of survival in Boston was 21 years, in Toronto 30, the two curves showing a marked separation from age 10. Although progressive pulmonary disease is the major cause of mortality in cystic fibrosis, the differences in growth and survival in these two patient groups, with very similar age-specific pulmonary function, suggest further examination of nutritional guidance and intervention in CF, especially regarding the traditional restriction of dietary fat.