Estimating chromophore distributions from multiwavelength photoacoustic images
Estimating chromophore distributions from multiwavelength photoacoustic images
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DOI：
10.1364/josaa.26.000443
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发表时间：
2009-02-01
影响因子：
1.9
通讯作者：
Beard, P. C.
中科院分区：
文献类型：
--
作者：
Cox, B. T.;Arridge, S. R.;Beard, P. C.
生物医学光声层析成像（PAT）可以提供高空间分辨率的生物医学软组织定性图像。然而，是否有可能给出准确的定量估计的空间变化的浓度的源的光声对比度内源性或外源性生色团仍然是一个悬而未决的问题。即使已知发色团的吸收光谱，该问题也是非线性和不适定的。我们描述了一个框架，获得这样的定量估计。当光学散射分布已知时，可以使用伴随和基于梯度的优化技术来恢复有助于整体组织吸收的各个发色团的浓度分布。当散射分布是未知的，先验知识的散射的波长依赖性被证明是足以克服的吸收-散射的非唯一性，并允许两个分布的生色团浓度和散射恢复从rmultilavelength光声图像。2009（C）美国光学学会
Biomedical photoacoustic tomography (PAT) can provide qualitative images of biomedical soft tissue with high spatial resolution. However, whether it is possible to give accurate quantitative estimates of the spatially varying concentrations of the sources of photoacoustic contrast-endogenous or exogenous chromophores-remains an open question. Even if the chromophores' absorption spectra are known the problem is nonlinear and ill-posed. We describe a framework for obtaining such quantitative estimates. When the optical scattering distribution is known, adjoint and gradient-based optimization techniques can be used to recover the concentration distributions of the individual chromophores that contribute to the overall tissue absorption. When the scattering distribution is unknown, prior knowledge of the wavelength dependence of the scattering is shown to be sufficient to overcome the absorption-scattering nonuniqueness and allow both distributions of chromophore concentrations and scattering to be recovered from rnultiwavelength photoacoustic images. 2009 (C) Optical Society of America