ADAR editing wobbles the MicroRNA world
ADAR editing wobbles the MicroRNA world
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DOI：
10.1021/cb700064h
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发表时间：
2007-04-01
影响因子：
4
通讯作者：
Carmichael, Gordon G.
中科院分区：
文献类型：
--
作者：
Das, Asis K.;Carmichael, Gordon G.
最近的工作表明，腺苷到肌苷的编辑发生在许多细胞microRNAs(MiRNAs)中。这种编辑被证明减少了一种miRNA的表达，并改变了另一种miRNA的靶标特异性。这大大改变了我们目前的观点，不仅增加了miRNAs及其潜在靶点的保存库，而且提供了如何监管它们并将其引导到替代靶点的机制。
Recent work reveals that adenosine-to-inosine editing occurs in a number of cellular microRNAs (miRNAs). Such editing is shown to diminish the expression of one miRNA and alter the target specificity of another. This changes our current views significantly by not only increasing the repertoire of miRNAs and their potential targets, but also providing mechanisms for how to regulate them and direct them to alternative targets.