Crystal Nucleation Kinetics from Induction Times and Metastable Zone Widths
Crystal Nucleation Kinetics from Induction Times and Metastable Zone Widths
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DOI：
10.1021/cg400139t
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发表时间：
2013-06-01
影响因子：
3.8
通讯作者：
ter Horst, Joop H.
中科院分区：
文献类型：
--
作者：
Kulkarni, Samir A.;Kadam, Somnath S.;ter Horst, Joop H.
我们比较了两个最近开发的方法，以确定在搅拌溶液中的晶体成核速率，以异烟酰胺（INA）在乙醇中作为一个例子。这两种开发的方法利用晶体成核的随机性，这是反映在诱导时间和亚稳区宽度的变化，在足够小的体积测量。这些方法提供了简单的实验访问的成核速率参数在工业上现实的结晶条件下的溶液。而介稳区宽度法劳动强度较小，诱导时间法具有较高的准确性，更容易分析。
We compare two recently developed methods to determine crystal nucleation rates in stirred solutions by using isonicotinamide (INA) in ethanol as an example. The two developed methods make use of the stochastic nature of crystal nucleation, which is reflected in induction time and metastable zone width variations measured in sufficiently small volumes. These methods give easy experimental access to the nucleation rate parameters in solution under industrially realistic crystallization conditions. While the metastable zone width method is less labor intensive, the induction time method has higher accuracy and is easier to analyze.