SENESCENCE-LIKE GROWTH ARREST INDUCED BY HYDROGEN-PEROXIDE IN HUMAN-DIPLOID FIBROBLAST F65 CELLS
SENESCENCE-LIKE GROWTH ARREST INDUCED BY HYDROGEN-PEROXIDE IN HUMAN-DIPLOID FIBROBLAST F65 CELLS
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DOI：
10.1073/pnas.91.10.4130
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发表时间：
1994-05-10
影响因子：
11.1
通讯作者：
AMES, BN
中科院分区：
文献类型：
--
作者：
CHEN, Q;AMES, BN
人二倍体成纤维细胞在一定数量的群体倍增后失去复制能力。我们使用这个实验系统来研究氧化损伤在细胞衰老中的作用。用H2O2处理细胞，
Human diploid fibroblast cells lose replicative potential after a certain number of population doublings. We use this experimental system to investigate the role of oxidative damage in cellular aging. Treating cells with H2O2 at