Preparation and characterization of fibroin/hyaluronic acid composite scaffold
Preparation and characterization of fibroin/hyaluronic acid composite scaffold
复制标题
丝素/透明质酸复合支架的制备及表征
DOI：
10.1016/j.ijbiomac.2009.02.004
复制
发表时间：
2009-05-01
影响因子：
8.2
通讯作者：
Cui, Fu-Zhai
中科院分区：
文献类型：
--
作者：
Ren, Yong-Juan;Zhou, Zi-You;Cui, Fu-Zhai
将透明质酸（HA）加入到丝素溶液中，制备丝素基多孔复合支架。HA对丝素支架的成孔性和亲水性有重要影响。水-丝素蛋白/HA支架具有高度均匀和互连的孔隙，孔隙率在90%以上，可控的孔径范围为123至253 μ m。丝素/HA支架的吸水率随着HA含量的增加而显著增加。含有限定含量范围（例如3- 6%）的HA，丝心蛋白基支架对原代神经细胞的亲和力得到改善。在6%HA/丝素蛋白支架中，神经球形成细胞从原来的聚集体迁移并紧密粘附在支架表面。(C)2009 Elsevier B. V.保留所有权利。
Hyaluronic acid (HA) was added into fibroin solution to prepare fibroin-based porous composite scaffolds. HA exhibited important effects on pore formation and hydrophilicity of fibroin-based scaffold. The aqueous-fibroin/HA scaffolds had highly homogeneous and interconnected pores with porosity of above 90% and controllable pore size ranging from 123 to 253 mu m. The water take-up of fibroin/HA scaffolds increased significantly with the increase of HA content. Containing HA at a defined content range, such as 3-6%, fibroin-based scaffolds' affinity to primary neural cells was improved. In 6%HA/fibroin scaffolds, neurosphere-forming cell migrated from their original aggregate and adhered tightly to the surface of scaffolds. (C) 2009 Elsevier B.V. All rights reserved.